MCAAD-3, Near-infrared probe for imaging of amyloid plaques (ab216983)

Overview

  • Product name
    MCAAD-3, Near-infrared probe for imaging of amyloid plaques
  • Description
    Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease
  • Biological description

    Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c. In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice. Learn more

  • Purity
    > 99%
  • CAS Number
    1625629-51-7
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    methyl (2Z,4E,6E)-2-cyano-7-[4-(dimethylamino)]hepta-2,4,6-trienoate
  • Molecular weight
    282.34
  • Molecular formula
    C17H18N2O2
  • Storage instructions
    Shipped at 4°C. Store at -20°C.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CN(C)c1ccc(/C=C/C=C/C=C(/C#N)C(=O)OC)cc1
  • Source

    Synthetic

References

This product has been referenced in:
  • Seo Y  et al. A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer's Disease. ACS Chem Neurosci 7:1474-1481 (2016). Read more (PubMed: 27576176) »
  • Tong H  et al. Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer?s disease. Acta Pharm Sin B 5:25-33 (2015). Read more (PubMed: 26579421) »
  • Fu H  et al. Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared ß-amyloidal-targeting probes. Chem Commun (Camb) 50:11875-8 (2014). Read more (PubMed: 25156492) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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