Melanin Concentrating Hormone (MCH) is the ligand of the somatostatin-like receptor 1 (SLC1 or MCH Receptor). This hormone induces melanosomal aggregation within melanophores and has orexigenic properties and is antagonistic to melanotropin. MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling MCH with ab174886 at 1/50 dilution. Detection utilised peroxidase conjugation of the secondary antibody and DAB staining.
Flow Cytometry - Anti-MCH antibody (ab174886)
Flow cytometric analysis of K562 cells labeling MCH with ab174886 at 1/10 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat anti-rabbit secondary antibodies were used for the analysis.