Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab199979 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-MCL1 antibody [Y37] (ab32087)

  • Form

    Liquid
  • Additional notes

    This is the blocking peptide for ab32087

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names

    • Bcl 2 related protein EAT/mcl1
    • Bcl-2-like protein 3
    • Bcl-2-related protein EAT/mcl1
    • BCL2 related
    • Bcl2-L-3
    • BCL2L3
    • EAT
    • Induced myeloid leukemia cell differentiation protein Mcl 1
    • Induced myeloid leukemia cell differentiation protein Mcl-1
    • MCL 1
    • MCL1
    • MCL1-ES
    • mcl1/EAT
    • MCL1_HUMAN
    • MCL1L
    • MCL1S
    • MGC104264
    • MGC1839
    • Myeloid Cell Leukemia 1
    • Myeloid cell leukemia ES
    • Myeloid cell leukemia sequence 1
    • Myeloid cell leukemia sequence 1 BCL2 related
    • Myeloid cell leukemia sequence 1 isoform 1
    • OTTHUMP00000032794
    • OTTHUMP00000032795
    • TM
    see all
  • Function

    Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
  • Sequence similarities

    Belongs to the Bcl-2 family.
  • Post-translational
    modifications

    Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
    Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
    Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
  • Cellular localization

    Membrane. Cytoplasm. Mitochondrion. Nucleus > nucleoplasm. Cytoplasmic, associated with mitochondria.
  • Information by UniProt

References

ab199979 has not yet been referenced specifically in any publications.

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