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  1. Link

    mcp1-antibody-ab9779.pdf

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Immunology Innate Immunity Chemokines Alpha Chemokines (CXC)
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Anti-MCP1 antibody (ab9779)

  • Datasheet
Reviews (1)Q&A (3)References (4)

Product price, shipping and contact information

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Key features and details

  • Rabbit polyclonal to MCP1
  • Reacts with: Rat
  • Isotype: unknown

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Overview

  • Product name

    Anti-MCP1 antibody
    See all MCP1 primary antibodies
  • Description

    Rabbit polyclonal to MCP1
  • Host species

    Rabbit
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    Highly pure (>98%) recombinant rMCAF/MCP-1 (rat Macrophage/Monocyte chemotactic protein-1)

  • General notes

    Although some customers have been successful in IHC we no longer batch test in this application.

Properties

  • Form

    Lyophilized:Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer

    No preservative, sterile filtered
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    unknown
  • Light chain type

    unknown
  • Research areas

    • Immunology
    • Innate Immunity
    • Chemokines
    • Alpha Chemokines (CXC)
    • Cardiovascular
    • Atherosclerosis
    • Vascular Inflammation
    • Leukocyte recruitment
    • Chemokines
    • Cancer
    • Cancer Metabolism
    • Response to hypoxia
    • Metabolism
    • Pathways and Processes
    • Metabolism processes
    • Hypoxia
    • Metabolism
    • Types of disease
    • Cancer
    • Metabolism
    • Types of disease
    • Heart disease

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Recombinant Protein

    • Recombinant human MCP1 protein (ab73866)

Target

  • Function

    Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
  • Sequence similarities

    Belongs to the intercrine beta (chemokine CC) family.
  • Post-translational
    modifications

    Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession P13500 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 24770 Rat
    • SwissProt: P14844 Rat
    • Unigene: 4772 Rat
    • Alternative names

      • C-C motif chemokine 2 antibody
      • CCL2 antibody
      • CCL2_HUMAN antibody
      • Chemokine (C C motif) ligand 2 antibody
      • GDCF 2 antibody
      • GDCF-2 antibody
      • GDCF2 antibody
      • HC11 antibody
      • HSMCR30 antibody
      • JE antibody
      • MCAF antibody
      • MCP 1 antibody
      • MCP-1 antibody
      • MCP1 antibody
      • MGC9434 antibody
      • Monocyte chemoattractant protein 1 antibody
      • Monocyte chemotactic and activating factor antibody
      • Monocyte chemotactic protein 1 antibody
      • Monocyte secretory protein JE antibody
      • SCYA2 antibody
      • Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je) antibody
      • Small inducible cytokine A2 antibody
      • Small inducible cytokine subfamily A (Cys Cys), member 2 antibody
      • Small-inducible cytokine A2 antibody
      • SMC CF antibody
      • SMC-CF antibody
      • SMCCF antibody
      see all

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (4)

    Publishing research using ab9779? Please let us know so that we can cite the reference in this datasheet.

    ab9779 has been referenced in 4 publications.

    • Abekura Y  et al. Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats. J Neuroinflammation 17:129 (2020). PubMed: 32331514
    • Oka M  et al. Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis. Sci Rep 10:8330 (2020). PubMed: 32433495
    • Zeng J  et al. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Rep 27:549-560.e6 (2019). PubMed: 30970257
    • Madrigal JL  et al. Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline. J Neurosci 29:263-7 (2009). Rat . PubMed: 19129402

    Customer reviews and Q&As

    Show All Reviews Q&A
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    1-4 of 4 Abreviews or Q&A

    Immunohistochemistry (PFA perfusion fixed frozen sections) abreview for Anti-MCP1 antibody

    Excellent
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (PFA perfusion fixed frozen sections)
    Blocking step
    Serum as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: RT°C
    Antigen retrieval step
    None
    Sample
    Rat Tissue sections (Injured spinel cord)
    Specification
    Injured spinel cord
    Permeabilization
    Yes - 0.2% Triton X100
    Fixative
    Paraformaldehyde
    Read More

    Dr. K. A.

    Verified customer

    Submitted Dec 12 2014

    Question

    Customer contacted us to inquire about positive controls in western blot.

    Read More

    Abcam community

    Verified customer

    Asked on Aug 08 2012

    Answer

    Thank you for contacting us.

    I have been in touch with our lab regarding your question about ab9779 anti-MCP1 antibody.

    This product has been raised against and tested with the MCP1 protein, ab9780 (https://www.abcam.com/mcp1-protein-ab9780.html). We would recommend use of this as a positive control for your experiments in western blot.



    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Use our products? Submit an Abreview. Earn rewards!
    https://www.abcam.com/abreviews

    Read More

    Abcam Scientific Support

    Answered on Aug 08 2012

    Question

    Hi. Is there a blocking peptide available for ab9779 or ab9669?

    Read More

    Abcam community

    Verified customer

    Asked on Sep 29 2011

    Answer

    Thank you for your inquiry. Both of these antibodies are polyclonals raised against full length recombinant proteins. Thus for blocking purposes, a full length recombinant protein would be recommended. I would like to recommend ab9780 for use with ab9779 and ab9670 for use with ab9669. I hope this information is helpful. Please do not hesitate to contact me if you have any additional questions.

    Read More

    Abcam Scientific Support

    Answered on Sep 29 2011

    Question

    We would like to inject a rat with the Antibody. We needed to know what concentration we need to use to neutilize the antibody.

    Read More

    Abcam community

    Verified customer

    Asked on Oct 31 2006

    Answer

    Thank you for your enquiry. With regards to Rabbit Anti-Rat MCP-1, we haven't tested this in vivo, but you can dilute in saline if needed. In our neutralization assay we used the anti rat MCP-1 to block the migration (chemotaxis) of human monocytes. I hope this information is of help, please do not hesitate to contact me should you have any additional questions.

    Read More

    Abcam Scientific Support

    Answered on Nov 01 2006

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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