Anti-MCP1 antibody (ab9779)
Key features and details
- Rabbit polyclonal to MCP1
- Reacts with: Rat
- Isotype: unknown
Overview
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Product name
Anti-MCP1 antibody
See all MCP1 primary antibodies -
Description
Rabbit polyclonal to MCP1 -
Host species
Rabbit -
Species reactivity
Reacts with: Rat -
Immunogen
Highly pure (>98%) recombinant rMCAF/MCP-1 (rat Macrophage/Monocyte chemotactic protein-1)
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General notes
Although some customers have been successful in IHC we no longer batch test in this application.
Properties
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Form
Lyophilized:Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
No preservative, sterile filtered -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
unknown -
Light chain type
unknown -
Research areas
Associated products
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Compatible Secondaries
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Recombinant Protein
Target
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Function
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. -
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family. -
Post-translational
modificationsProcessing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 24770 Rat
- SwissProt: P14844 Rat
- Unigene: 4772 Rat
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Alternative names
- C-C motif chemokine 2 antibody
- CCL2 antibody
- CCL2_HUMAN antibody
see all
Datasheets and documents
References (4)
ab9779 has been referenced in 4 publications.
- Abekura Y et al. Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats. J Neuroinflammation 17:129 (2020). PubMed: 32331514
- Oka M et al. Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis. Sci Rep 10:8330 (2020). PubMed: 32433495
- Zeng J et al. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Rep 27:549-560.e6 (2019). PubMed: 30970257
- Madrigal JL et al. Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline. J Neurosci 29:263-7 (2009). Rat . PubMed: 19129402
