Anti-MCP1 antibody [ECE.2] (ab8101)
Key features and details
- Rat monoclonal [ECE.2] to MCP1
- Suitable for: IHC-Fr
- Reacts with: Mouse
- Isotype: IgG1
Overview
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Product name
Anti-MCP1 antibody [ECE.2]
See all MCP1 primary antibodies -
Description
Rat monoclonal [ECE.2] to MCP1 -
Host species
Rat -
Specificity
The antibody reacts with murine JE / MCP-1. -
Tested Applications & Species
Application Species IHC-Fr Mouse -
Immunogen
Synthetic peptide:
LFKTASALRSSAPLNVKLTRKSEANASTT
, corresponding to C terminal amino acids 102-130 of Mouse MCP1 -
Positive control
- Recombinant mouse MCP1 protein (ab9901) can be used as a positive control in WB.
-
General notes
Monocyte chemotactic protein-1 (MCP-1) is also known as MCAF.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
0.2 µm filtered antibody solution -
Clonality
Monoclonal -
Clone number
ECE.2 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab8101 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
Application | Species |
---|---|
IHC-Fr |
Mouse
|
Application | Abreviews | Notes |
---|---|---|
IHC-Fr |
Use at an assay dependent concentration.
|
Notes |
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IHC-Fr
Use at an assay dependent concentration. |
Target
-
Function
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. -
Sequence similarities
Belongs to the intercrine beta (chemokine CC) family. -
Post-translational
modificationsProcessing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 20296 Mouse
- SwissProt: P10148 Mouse
- Unigene: 290320 Mouse
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Alternative names
- C-C motif chemokine 2 antibody
- CCL2 antibody
- CCL2_HUMAN antibody
see all
Images
Protocols
Datasheets and documents
References (22)
ab8101 has been referenced in 22 publications.
- Voss S et al. Macrophage Migration Inhibitory Factor (MIF) Expression Increases during Myocardial Infarction and Supports Pro-Inflammatory Signaling in Cardiac Fibroblasts. Biomolecules 9:N/A (2019). PubMed: 30678084
- Yang C et al. Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques. J Exp Med 216:1182-1198 (2019). PubMed: 30940720
- Deng B et al. Progressive Degeneration and Inhibition of Peripheral Nerve Regeneration in the SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis. Cell Physiol Biochem 46:2358-2372 (2018). PubMed: 29742495
- Curry ZA et al. Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy. J Pharmacol Exp Ther 366:169-183 (2018). PubMed: 29540562
- Brun P et al. Herpes Simplex Virus Type 1 Infects Enteric Neurons and Triggers Gut Dysfunction via Macrophage Recruitment. Front Cell Infect Microbiol 8:74 (2018). IHC-P . PubMed: 29600197