Overview

  • Product name

  • Description

    Rabbit polyclonal to MCP4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: Indirect ELISA, Sandwich ELISA, Neutralising, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Highly pure (>98%) recombinant Human MCP4

Properties

  • Form

    Lyophilised:Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer

    pH: 7.20
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab110609 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Indirect ELISA Use a concentration of 0.5 - 2 µg/ml. (using 100 µl/well antibody solution) allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human MCP4.
Sandwich ELISA Use a concentration of 0.5 - 2 µg/ml. Using ab83122 as the detection antibody and ab110609 as the capture antibody, the detection limit for recombinant Human MCP4 is 0.2 - 0.4 ng/well, using 100 µl/well antibody solution.
Neutralising Use a concentration of 1 - 1.5 µg/ml. to yield one-half maximal inhibition [ND50] of the biological activity of MCP4 (30.0 ng/ml)
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 11 kDa. The detection limit for recombinant Human MCP4 is 3.0 - 4.0 ng/lane, under either reducing or non-reducing conditions.

Target

  • Function

    Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
  • Tissue specificity

    Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
  • Sequence similarities

    Belongs to the intercrine beta (chemokine CC) family.
  • Post-translational
    modifications

    One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • C-C motif chemokine 13 antibody
    • CCL13 antibody
    • CCL13_HUMAN antibody
    • Chemokine (C C motif) ligand 13 antibody
    • CK beta 10 antibody
    • CK-beta-10 antibody
    • CKb10 antibody
    • MCP-4 antibody
    • MGC17134 antibody
    • Monocyte chemoattractant protein 4 antibody
    • Monocyte chemotactic protein 4 antibody
    • NCC 1 antibody
    • NCC-1 antibody
    • NCC1 antibody
    • New CC chemokine 1 antibody
    • SCYA13 antibody
    • SCYL1 antibody
    • short chain antibody
    • Small inducible cytokine A13 precursor antibody
    • Small inducible cytokine subfamily A (Cys Cys) member 13 antibody
    • Small-inducible cytokine A13 antibody
    see all

References

ab110609 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab110609.
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