Overview

  • Product name

  • Description

    Rabbit polyclonal to MCPIP1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WB, Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human MCPIP1 aa 331-358 conjugated to keyhole limpet haemocyanin.
    Sequence:

    RSVADELRANALLSPPRAPSKDKNGRRP


    Database link: Q5D1E8

  • Positive control

    • IHC-P: Human adrenal gland tissue. WB: HepG2 cell lysate. Flow cytometry: HepG2 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab230502 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB 1/1000. Predicted molecular weight: 65 kDa.
Flow Cyt 1/10 - 1/50.

Target

  • Function

    Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.
  • Sequence similarities

    Belongs to the ZC3H12 family.
    Contains 1 C3H1-type zinc finger.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • dJ423B22.1 antibody
    • MCP 1 treatment-induced protein antibody
    • MCP-induced protein 1 antibody
    • MCP1-induced protein antibody
    • MCPIP 1 antibody
    • MCPIP antibody
    • Ribonuclease ZC3H12A antibody
    • RP3-423B22.1 antibody
    • ZC12A_HUMAN antibody
    • ZC3H 12A antibody
    • ZC3H12 A antibody
    • Zc3h12a antibody
    • Zinc finger CCCH domain-containing protein 12A antibody
    • Zinc finger CCCH type containing 12A antibody
    see all

Images

  • Anti-MCPIP1 antibody (ab230502) at 1/1000 dilution + HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate at 35 µg

    Predicted band size: 65 kDa

  • Flow cytometric analysis of HepG2 (human liver hepatocellular carcinoma cell line) cells labelling MCPIP1 using ab230502 at 1/10 dilution (green) compared to the control (blue). 

     FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

  • Formalin-fixed, paraffin-embedded human adrenal gland tissue stained for MCPIP1 using ab230502 at 1/100 dilution in immunohistochemical analysis.

References

ab230502 has not yet been referenced specifically in any publications.

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