Anti-mMCP-4 antibody (ab92368)
Key features and details
- Goat polyclonal to mMCP-4
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-mMCP-4 antibody -
Description
Goat polyclonal to mMCP-4 -
Host species
Goat -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Synthetic peptide corresponding to Mouse mMCP-4 aa 114-126 (internal sequence) (Cysteine residue).
Sequence:KLQKKAKETPSVN
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab92368 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab92368 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P | (1) |
Use at an assay dependent concentration.
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Notes |
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IHC-P
Use at an assay dependent concentration. |
Target
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Function
Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-
-Ile-5' bond of angiotensin I and the 'Phe-20-
-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-
-His-9' bond of angiotensin I and the 'Phe-4-
-Ala-5' and 'Tyr-10-
-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. -
Tissue specificity
Submucosal mast cells. In femoral muscle, detected in myocytes but not in mast cells. -
Sequence similarities
Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain. - Information by UniProt
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Database links
- Entrez Gene: 17227 Mouse
- SwissProt: P21812 Mouse
- Unigene: 439684 Mouse
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Alternative names
- Mast cell protease 4 antibody
- Mcp 4 antibody
- Mcpt4 antibody
see all
Datasheets and documents
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Datasheet download
References (3)
ab92368 has been referenced in 3 publications.
- Terai K et al. Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice. Int J Mol Sci 21:N/A (2020). PubMed: 33050674
- Mackey E et al. Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood. Proc Natl Acad Sci U S A 117:23751-23761 (2020). PubMed: 32917815
- Rowbotham SP et al. H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression. Nat Commun 9:4559 (2018). PubMed: 30455465