• Product name

  • Description

    Rabbit polyclonal to MCT-1
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant fragment corresponding to Human MCT-1 aa 39-176.
    Database link: AAH01013

  • Positive control

    • Jurkat whole cell lysate, 293T and A431 cell lysates
  • General notes

    Previously labelled as Malignant T cell amplified sequence 1. 


  • Form

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.00
    Preservative: 0.025% Proclin
    Constituents: PBS, 1% BSA, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab102678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 21 kDa.


  • Function

    Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3.
  • Tissue specificity

    Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
  • Sequence similarities

    Belongs to the MCTS1 family.
    Contains 1 PUA domain.
  • Domain

    The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly trough interaction with other proteins.
  • Post-translational

    Phosphorylation is critical for stabilization and promotion of cell proliferation.
  • Cellular localization

    Cytoplasm. Nuclear relocalization after DNA damage.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ39637 antibody
    • Malignant T cell amplified sequence 1 antibody
    • Malignant T cell-amplified sequence 1 antibody
    • MCT 1 antibody
    • MCT-1 antibody
    • MCT1 antibody
    • MCTS 1 antibody
    • MCTS1 antibody
    • MCTS1_HUMAN antibody
    • Multiple copies T cell malignancies 1 antibody
    • Multiple copies T cell malignancies antibody
    • Multiple copies T-cell malignancies antibody
    • Oncogene MCT 1 antibody
    • Oncogene MCT1 antibody
    see all


  • Anti-MCT-1 antibody (ab102678) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size: 21 kDa

    12% SDS-PAGE


ab102678 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab102678.
Please use the links above to contact us or submit feedback about this product.

For licensing inquiries, please contact partnerships@abcam.com

Sign up