Key features and details
- Goat polyclonal to MCT2
- Suitable for: ELISA, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MCT2 antibody
See all MCT2 primary antibodies
DescriptionGoat polyclonal to MCT2
Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Chimpanzee, Monkey, Gorilla, Common marmoset
- Human testis tissue; A549 lysate.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab129290 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 52 kDa.|
|IHC-P||Use a concentration of 2.5 - 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionProton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter.
Tissue specificityHigh expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.
Sequence similaritiesBelongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Cellular localizationCell membrane.
- Information by UniProt
- MCT 2 antibody
- MCT antibody
- Monocarboxylate transporter 2 antibody
ab129290 has been referenced in 3 publications.
- Giatromanolaki A et al. Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis. Med Oncol 36:76 (2019). PubMed: 31342270
- Lund J et al. Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism. Sci Rep 8:9814 (2018). PubMed: 29959350
- Eilertsen M et al. Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival. PLoS One 9:e105038 (2014). IHC-P ; Human . PubMed: 25225794