Overview

  • Product name

    Mdivi-1, Drp1 inhibitor
  • Description

    Selective, cell-permeable mitochondrial division Drp1 inhibitor
  • Biological description

    Selective, cell-permeable mitochondrial division Drp1 inhibitor (IC50 = 10 μM). Inhibits mitochondrial outer membrane permeabilization to prevent apoptosis in vitro. Anti-stroke and neuroprotective agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    338967-87-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone
  • Molecular weight

    353.23
  • Molecular formula

    C15H10Cl2N2O2S
  • PubChem identifier

    3825829
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gharanei M  et al. Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. PLoS One 8:e77713 (2013). Read more (PubMed: 24147064) »
  • Park SW  et al. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci 52:2837-43 (2011). Read more (PubMed: 21372007) »
  • Cassidy-Stone A  et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell 14:193-204 (2008). Read more (PubMed: 18267088) »
See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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