Key features and details
- Selective, cell-permeable mitochondrial division Drp1 inhibitor
- CAS Number: 338967-87-6
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameMdivi-1, Drp1 inhibitor
DescriptionSelective, cell-permeable mitochondrial division Drp1 inhibitor
Biological descriptionSelective, cell-permeable mitochondrial division Drp1 inhibitor (IC50 = 10 μM). Inhibits mitochondrial outer membrane permeabilization to prevent apoptosis in vitro. Anti-stroke and neuroprotective agent. Active in vivo and in vitro.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144589 has been referenced in 7 publications.
- Zhang L et al. Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells. Exp Ther Med 22:696 (2021). PubMed: 33986860
- Tusskorn O et al. Mitochondrial division inhibitor-1 potentiates cisplatin-induced apoptosis via the mitochondrial death pathway in cholangiocarcinoma cells. Biomed Pharmacother 111:109-118 (2019). PubMed: 30579250
- Yang SK et al. Mitochondria-Targeted Peptide SS31 Attenuates Renal Tubulointerstitial Injury via Inhibiting Mitochondrial Fission in Diabetic Mice. Oxid Med Cell Longev 2019:2346580 (2019). PubMed: 31281569
- Park HS et al. Swine Influenza Virus Induces RIPK1/DRP1-Mediated Interleukin-1 Beta Production. Viruses 10:N/A (2018). PubMed: 30096906
- Hang W et al. Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux. Front Pharmacol 9:1121 (2018). PubMed: 30337876
- Yin J et al. Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway. Toxicol In Vitro 51:1-10 (2018). PubMed: 29729358
- Shen Z et al. PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window. Autophagy 13:473-485 (2017). PubMed: 28103118