MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor (ab145601)

Overview

  • Product name

    MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor
  • Description

    Potent and selective cell-permeable calpain and cathepsin B inhibitor
  • Biological description

    Potent and selective cell-permeable calpain and cathepsin B inhibitor (IC50 = 11 nM, calpain, Ki values are 10 and 25 nM for calpain and cathepsin B respectively). Shows neuroprotective effects in vivo. Blood-brain barrier permeable.
  • Purity

    > 95%
  • CAS Number

    88191-84-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    benzyl N-[3-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]butan-2-yl]carbamate
  • Molecular weight

    382.45
  • Molecular formula

    C22H26N2O4
  • PubChem identifier

    9907994
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Marinho FA  et al. The calpain inhibitor MDL28170 induces the expression of apoptotic markers in Leishmania amazonensis promastigotes. PLoS One 9:e87659 (2014). Read more (PubMed: 24498160) »
  • Kawamura M  et al. Calpain inhibitor MDL 28170 protects hypoxic-ischemic brain injury in neonatal rats by inhibition of both apoptosis and necrosis. Brain Res 1037:59-69 (2005). Read more (PubMed: 15777753) »
  • Kunz S  et al. The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia. Pain 110:409-18 (2004). Read more (PubMed: 15275793) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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