Key features and details
- Potent and selective cell-permeable calpain and cathepsin B inhibitor
- CAS Number: 88191-84-8
- Purity: > 95%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameMDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor
DescriptionPotent and selective cell-permeable calpain and cathepsin B inhibitor
Biological descriptionPotent and selective cell-permeable calpain and cathepsin B inhibitor (IC50 = 11 nM, calpain, Ki values are 10 and 25 nM for calpain and cathepsin B respectively). Shows neuroprotective effects in vivo. Blood-brain barrier permeable.
Chemical namebenzyl N-[3-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]butan-2-yl]carbamate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145601 has been referenced in 2 publications.
- Xu C et al. Overexpression of calpain-1 predicts poor outcome in patients with colorectal cancer and promotes tumor cell progression associated with downregulation of FLNA. Oncol Rep 41:3424-3434 (2019). PubMed: 31002357
- Wan L et al. M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation. Front Mol Neurosci 11:287 (2018). PubMed: 30186110