MDL 72222, 5-HT3 receptor antagonist (ab146635)

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Chemical Structure - MDL 72222, 5-HT<sub>3</sub> receptor antagonist (ab146635)

    Key features and details

    • Selective 5-HT3 receptor antagonist
    • CAS Number: 40796-97-2
    • Purity: > 99%
    • Soluble in ethanol to 100 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      MDL 72222, 5-HT3 receptor antagonist

    • Description

      Selective 5-HT3 receptor antagonist

    • Alternative names

      • 1 alpha H, 3 alpha, 5 alpha H-tropan-3-yl-3,5-dichlorobenzoate
      • 3-Tropanyl-3,5-dichlorobenzoate
      • Bemesetron
      • MDL-72222
      • Tropanyl 3,5-dichlorobenzoate
      see all

    • Biological description

      Selective 5-HT3 receptor antagonist. Shows antiemetic effects in vivo. Suppresses voluntary ethanol consumption that is mediated by 5-HT3 receptor in rats.

    • Purity

      > 99%

    • CAS Number

      40796-97-2

    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      3,5-Dichlorobenzoic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

    • Molecular weight

      314.21

    • Molecular formula

      C15H17Cl2NO2

    • Storage instructions

      Store at room temperature.

    • Solubility overview

      Soluble in ethanol to 100 mM and in DMSO to 100 mM

    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CN3[C@@H]1CC[C@H]3C[C@H](C1)OC(=O)c2cc(Cl)cc(Cl)c2

    • Source

      Synthetic

    Images

    • Chemical Structure - MDL 72222, 5-HT<sub>3</sub> receptor antagonist (ab146635)
      Chemical Structure - MDL 72222, 5-HT3 receptor antagonist (ab146635)
      2D chemical structure image of ab146635, MDL 72222, 5-HT3 receptor antagonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab146635? Please let us know so that we can cite the reference in this datasheet.

    ab146635 has not yet been referenced specifically in any publications.

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