MDL 72222, 5-HT3 receptor antagonist (ab146635)

Overview

  • Product name

    MDL 72222, 5-HT3 receptor antagonist
  • Description

    Selective 5-HT3 receptor antagonist
  • Alternative names

    • 1 alpha H, 3 alpha, 5 alpha H-tropan-3-yl-3,5-dichlorobenzoate
    • 3-Tropanyl-3,5-dichlorobenzoate
    • Bemesetron
    • MDL-72222
    • Tropanyl 3,5-dichlorobenzoate
    see all
  • Biological description

    Selective 5-HT3 receptor antagonist. Shows antiemetic effects in vivo. Suppresses voluntary ethanol consumption that is mediated by 5-HT3 receptor in rats.

  • Purity

    > 99%
  • CAS Number

    40796-97-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3,5-Dichlorobenzoic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • Molecular weight

    314.21
  • Molecular formula

    C15H17Cl2NO2
  • Storage instructions

    Store at room temperature.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN3[C@@H]1CC[C@H]3C[C@H](C1)OC(=O)c2cc(Cl)cc(Cl)c2
  • Source

    Synthetic

References

This product has been referenced in:

  • Jinka TR  et al. Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii). J Neurochem 122:934-40 (2012). Read more (PubMed: 22697356) »
  • Kos T  et al. Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice. Eur Neuropsychopharmacol 16:297-310 (2006). Read more (PubMed: 16288851) »
  • Fozard JR MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch Pharmacol 326:36-44 (1984). Read more (PubMed: 6472484) »

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