Product nameMDL 72222, 5-HT3 receptor antagonist
DescriptionSelective 5-HT3 receptor antagonist
- 1 alpha H, 3 alpha, 5 alpha H-tropan-3-yl-3,5-dichlorobenzoate
Selective 5-HT3 receptor antagonist. Shows antiemetic effects in vivo. Suppresses voluntary ethanol consumption that is mediated by 5-HT3 receptor in rats.
Chemical name3,5-Dichlorobenzoic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Storage instructionsStore at room temperature.
Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 100 mM
Toxic, refer to SDS for further information.
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This product has been referenced in:
- Jinka TR et al. Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii). J Neurochem 122:934-40 (2012). Read more (PubMed: 22697356) »
- Kos T et al. Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice. Eur Neuropsychopharmacol 16:297-310 (2006). Read more (PubMed: 16288851) »
- Fozard JR MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch Pharmacol 326:36-44 (1984). Read more (PubMed: 6472484) »