Product nameAnti-Measles nucleoprotein antibody
See all Measles nucleoprotein primary antibodies
DescriptionRabbit polyclonal to Measles nucleoprotein
Tested applicationsSuitable for: ELISA, WBmore details
Species reactivityReacts with Measles virus. Not yet tested in other species.
Recombinant full length protein.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferConstituent: Whole serum
Our Abpromise guarantee covers the use of ab23974 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||1/2000 - 1/10000.|
|WB||1/200 - 1/1000. Predicted molecular weight: 58 kDa.|
RelevanceInvolved in the encapsidating of the genome in a ratio of 1 N per 6 ribonucleotides, resulting in the protection from nucleases. The nucleocapsid (NC) has an helical structure with either 12.35 or 11.64 N per turn, approximately 20nm in diameter, with a hollow central cavity approximately 5nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest
Cellular localizationVirion. Host cytoplasm.
- Measles nucleocapsid protein antibody
- N antibody
- NP antibody
- Nucleocapsid protein antibody
This product has been referenced in:
- Hanauer JR et al. Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors. Mol Ther Oncolytics 3:16003 (2016). WB . Read more (PubMed: 27119117) »
- Stewart CE et al. Inhibitors of the interferon response enhance virus replication in vitro. PLoS One 9:e112014 (2014). Read more (PubMed: 25390891) »