Key features and details
- Non-competitive antagonist of nicotinic receptors
- CAS Number: 826-39-1
- Soluble in water to 100 mM and in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Product nameMecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors
DescriptionNon-competitive antagonist of nicotinic receptors
Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 µM, 3.6 µM and 6.9 µM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice.
Chemical nameN,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120459 has been referenced in 3 publications.
- Gawel K et al. Acquisition and reinstatement of ethanol-induced conditioned place preference in rats: Effects of the cholinesterase inhibitors donepezil and rivastigmine. J Psychopharmacol 30:676-87 (2016). PubMed: 27097732
- Luo R et al. Direct and GABA-mediated indirect effects of nicotinic ACh receptor agonists on striatal neurones. J Physiol 591:203-17 (2013). PubMed: 23045343
- Singh NS et al. Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells. Cell Signal 25:2634-45 (2013). PubMed: 24012499