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Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors (ab120459)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors (ab120459)

    Key features and details

    • Non-competitive antagonist of nicotinic receptors
    • CAS Number: 826-39-1
    • Soluble in water to 100 mM and in DMSO to 75 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors
    • Description

      Non-competitive antagonist of nicotinic receptors
    • Biological description

      Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 µM, 3.6 µM and 6.9 µM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice.

    • CAS Number

      826-39-1
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
    • Molecular weight

      203.75
    • Molecular formula

      C11H21N.HCl
    • PubChem identifier

      13221
    • Storage instructions

      Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM and in DMSO to 75 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      Cl.CNC2(C)C1CCC(C1)C2(C)C
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Ligand-Gated Ion Channels
      • nAch Receptors
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Nicotinic
      • General
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Nicotinic
      • General
      • Antagonists
      • Biochemicals
      • Research Area
      • Addiction
      • Nicotinic
      • General
      • Biochemicals
      • Research Area
      • Addiction
      • Nicotinic
      • General
      • Antagonists
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Nicotinic
      • General
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Nicotinic
      • General
      • Antagonists
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Nicotinic
      • General
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Nicotinic
      • General
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Nicotinic
      • General
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Nicotinic
      • General
      • Antagonists

    Associated products

      Images

      • Chemical Structure - Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors (ab120459)
        Chemical Structure - Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors (ab120459)
        2D chemical structure image of ab120459, Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download
      • COA

      References (3)

      Publishing research using ab120459? Please let us know so that we can cite the reference in this datasheet.

      ab120459 has been referenced in 3 publications.

      • Gawel K  et al. Acquisition and reinstatement of ethanol-induced conditioned place preference in rats: Effects of the cholinesterase inhibitors donepezil and rivastigmine. J Psychopharmacol 30:676-87 (2016). PubMed: 27097732
      • Luo R  et al. Direct and GABA-mediated indirect effects of nicotinic ACh receptor agonists on striatal neurones. J Physiol 591:203-17 (2013). PubMed: 23045343
      • Singh NS  et al. Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells. Cell Signal 25:2634-45 (2013). PubMed: 24012499

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