Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors (ab120459)
- Datasheet
- References (3)
Overview
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Product name
Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors -
Description
Non-competitive antagonist of nicotinic receptors -
Biological description
Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 µM, 3.6 µM and 6.9 µM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice. -
CAS Number
826-39-1 -
Chemical structure
Properties
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Chemical name
N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride -
Molecular weight
203.75 -
Molecular formula
C11H21N.HCl -
PubChem identifier
13221 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.CNC2(C)C1CCC(C1)C2(C)C -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Ostroumov K et al. Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur Biophys J 37:393-402 (2008). Read more (PubMed: 17938901) »
- Rabenstein RL et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl) 189:395-401 (2006). Read more (PubMed: 17016705) »
- Papke RL et al. Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. J Pharmacol Exp Ther 297:646-56 (2001). Read more (PubMed: 11303054) »
