Overview

  • Product name

    Mecamylamine hydrochloride, non-competitive antagonist of nicotinic receptors
  • Description

    Non-competitive antagonist of nicotinic receptors
  • Biological description

    Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain barrier permeable. Blocks various different nAChR types, (IC50 values are 640 nM, 2.5 µM, 3.6 µM and 6.9 µM at α3β4, α4β2, α3β2 and α7 receptors, respectively). Blocks most physiological, behavioural and reinforcing effects of nicotine. Displays antidepressant-like effects in mice.
  • CAS Number

    826-39-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ostroumov K  et al. Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur Biophys J 37:393-402 (2008). Read more (PubMed: 17938901) »
  • Rabenstein RL  et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl) 189:395-401 (2006). Read more (PubMed: 17016705) »
  • Papke RL  et al. Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. J Pharmacol Exp Ther 297:646-56 (2001). Read more (PubMed: 11303054) »
See all 3 Publications for this product

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