Overview

  • Product name

    Meclofenamate sodium, competitive COX1 and COX2 inhibitor
  • Description

    Non-selective competitive COX1 and COX2 inhibitor; 5-lipoxygenase inhibitor
  • Biological description

    Non-selective, competitive COX1 and COX2 inhibitor (IC50 values are 1.5 and 9.6 μM, respectively). Also inhibits 5-lipoxygenase (IC50 = 46.8 μM) and human Kv2.1 channels (IC50 = 155.9 μM). Analgesic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    6385-02-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lee YT & Wang Q Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid. Eur J Pharmacol 378:349-56 (1999). Read more (PubMed: 10493112) »
  • Ouellet M & Percival MD Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J 306 ( Pt 1):247-51 (1995). Read more (PubMed: 7864817) »
  • Boctor AM  et al. Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro. Prostaglandins Leukot Med 23:229-38 (1986). Read more (PubMed: 3020588) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141552.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up