Overview

  • Product name

  • Description

    Rabbit polyclonal to MED12
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human MED12 aa 1742-2011.
    Database link: Q93074

  • Positive control

    • IHC-P: Human brain and gastric cancer tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab234877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
  • Tissue specificity

    Ubiquitous.
  • Involvement in disease

    Defects in MED12 are the cause of Opitz-Kaveggia syndrome (OKS) [MIM:305450]; also known as FG syndrome type 1 (FGS1) or FG syndrome (FGS). OKS is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
    Defects in MED12 are the cause of Lujan-Fryns syndrome (LUJFRYS) [MIM:309520]; also known as X-linked mental retardation with marfanoid habitus. Clinically, Lujan-Fryns syndrome can be distinguished from Opitz-Kaveggia syndrome by tall stature, hypernasal voice, hyperextensible digits and high nasal root.
  • Sequence similarities

    Belongs to the Mediator complex subunit 12 family.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Activator recruited cofactor 240 kDa component antibody
    • Activator-recruited cofactor 240 kDa component antibody
    • ARC240 antibody
    • CAG repeat protein 45 antibody
    • CAGH45 antibody
    • HOPA antibody
    • KIAA0192 antibody
    • MED12 antibody
    • MED12_HUMAN antibody
    • Mediator complex subunit 12 antibody
    • Mediator of RNA polymerase II transcription subunit 12 antibody
    • OPA containing protein antibody
    • OPA-containing protein antibody
    • Thyroid hormone receptor associated protein complex 230 kDa component antibody
    • Thyroid hormone receptor-associated protein complex 230 kDa component antibody
    • TNRC11 antibody
    • Trap230 antibody
    • Trinucleotide repeat containing gene 11 protein antibody
    • Trinucleotide repeat-containing gene 11 protein antibody
    see all

Images

  • Paraffin-embedded human gastric cancer tissue stained for MED12 using ab234877 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human brain tissue stained for MED12 using ab234877 at 1/100 dilution in immunohistochemical analysis.

References

ab234877 has not yet been referenced specifically in any publications.

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