Anti-MEF2D antibody (ab93257)
Key features and details
- Rabbit polyclonal to MEF2D
- Reacts with: Recombinant fragment
- Isotype: IgG
Overview
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Product name
Anti-MEF2D antibody
See all MEF2D primary antibodies -
Description
Rabbit polyclonal to MEF2D -
Host species
Rabbit -
Species reactivity
Reacts with: Recombinant fragment
Predicted to work with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to the N terminal residues of Human MEF2D.
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Purity >90% -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Target
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Function
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis. -
Sequence similarities
Belongs to the MEF2 family.
Contains 1 MADS-box domain.
Contains 1 Mef2-type DNA-binding domain. -
Developmental stage
Present in myotubes and also in undifferentiated myoblasts. -
Domain
The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity. -
Post-translational
modificationsPhosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phsophorylation on Ser-180 can be enhanced by EGF.
Acetylated on Lys-439 by CREBBP. Deacetylated by SIRT1.
Sumoylated on Lys-439 by SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3.
Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation. -
Cellular localization
Nucleus. Translocated by HDAC4 to nuclear dots. - Information by UniProt
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Database links
- Entrez Gene: 4209 Human
- Entrez Gene: 17261 Mouse
- Entrez Gene: 81518 Rat
- Omim: 600663 Human
- SwissProt: Q14814 Human
- SwissProt: Q63943 Mouse
- SwissProt: O89038 Rat
- Unigene: 314327 Human
see all -
Alternative names
- DKFZp686I1536 antibody
- MADS box transcription factor 2 polypeptide D antibody
- Mef2d antibody
see all
Datasheets and documents
References (0)
ab93257 has not yet been referenced specifically in any publications.