Anti-MEF2D antibody (ab93257)

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Key features and details

  • Rabbit polyclonal to MEF2D
  • Reacts with: Recombinant fragment
  • Isotype: IgG

Overview

  • Product name

    Anti-MEF2D antibody
    See all MEF2D primary antibodies

  • Description

    Rabbit polyclonal to MEF2D

  • Host species

    Rabbit

  • Species reactivity

    Reacts with: Recombinant fragment
    Predicted to work with: Mouse, Rat, Human

  • Immunogen

    Synthetic peptide corresponding to the N terminal residues of Human MEF2D.

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

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Properties

Target

  • Function

    Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.

  • Sequence similarities

    Belongs to the MEF2 family.
    Contains 1 MADS-box domain.
    Contains 1 Mef2-type DNA-binding domain.

  • Developmental stage

    Present in myotubes and also in undifferentiated myoblasts.

  • Domain

    The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.

  • Post-translational
    modifications

    Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phsophorylation on Ser-180 can be enhanced by EGF.
    Acetylated on Lys-439 by CREBBP. Deacetylated by SIRT1.
    Sumoylated on Lys-439 by SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3.
    Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.

  • Cellular localization

    Nucleus. Translocated by HDAC4 to nuclear dots.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • DKFZp686I1536 antibody
    • MADS box transcription factor 2 polypeptide D antibody
    • Mef2d antibody
    • MEF2D_HUMAN antibody
    • Myocyte enhancer factor 2D antibody
    • Myocyte specific enhancer factor 2, polypeptide D antibody
    • Myocyte specific enhancer factor 2D antibody
    • Myocyte-specific enhancer factor 2D antibody
    see all

References (0)

Publishing research using ab93257? Please let us know so that we can cite the reference in this datasheet.

ab93257 has not yet been referenced specifically in any publications.

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