Key features and details
- Rabbit polyclonal to MEF2D
- Reacts with: Recombinant fragment
- Isotype: IgG
Product nameAnti-MEF2D antibody
See all MEF2D primary antibodies
DescriptionRabbit polyclonal to MEF2D
Species reactivityReacts with: Recombinant fragment
Predicted to work with: Mouse, Rat, Human
Synthetic peptide corresponding to the N terminal residues of Human MEF2D.
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Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferpH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPurity >90%
FunctionTranscriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
Sequence similaritiesBelongs to the MEF2 family.
Contains 1 MADS-box domain.
Contains 1 Mef2-type DNA-binding domain.
Developmental stagePresent in myotubes and also in undifferentiated myoblasts.
DomainThe beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.
modificationsPhosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phsophorylation on Ser-180 can be enhanced by EGF.
Acetylated on Lys-439 by CREBBP. Deacetylated by SIRT1.
Sumoylated on Lys-439 by SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3.
Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
Cellular localizationNucleus. Translocated by HDAC4 to nuclear dots.
- Information by UniProt
- DKFZp686I1536 antibody
- MADS box transcription factor 2 polypeptide D antibody
- Mef2d antibody
ab93257 has not yet been referenced specifically in any publications.