Overview

  • Product name

  • Description

    Rabbit polyclonal to MEIS1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human MEIS1 aa 42-69.
    Sequence:

    GPPLHSHQYPHTAHTNAMAPSMGSSVND


    Database link: O00470

  • Positive control

    • ICC/IF: HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab222246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton-X 100

Target

  • Function

    Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
  • Tissue specificity

    Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
  • Involvement in disease

    Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.
  • Sequence similarities

    Belongs to the TALE/MEIS homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Homeo box protein Meis1 antibody
    • Homeobox protein Meis1 antibody
    • Leukemogenic homolog protein antibody
    • MEIS 1 antibody
    • Meis homeo box 1 antibody
    • Meis homeobox 1 antibody
    • Meis1 antibody
    • Meis1 mouse homolog antibody
    • Meis1 myeloid ecotropic viral integration site 1 homolog antibody
    • Meis1 myeloid ecotropic viral integration site 1 homolog mouse antibody
    • MEIS1 protein antibody
    • MEIS1_HUMAN antibody
    • MGC43380 antibody
    • Myeloid ecotropic viral integration site 1 homolog antibody
    • WUGSC:H NH0444B04.1 antibody
    see all

Images

  • 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for MEIS1 (green) using ab222246 at 4 µg/ml in ICC/IF.

References

ab222246 has not yet been referenced specifically in any publications.

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