Anti-MEIS1 antibody [EPR5781] (ab124686)


  • Product name
    Anti-MEIS1 antibody [EPR5781]
    See all MEIS1 primary antibodies
  • Description
    Rabbit monoclonal [EPR5781] to MEIS1
  • Host species
  • Specificity
    The immunogen of ab124686 is, according to BLAST results, conserved (57%) with human MEIS2. According to this, the antibody might cross-react with MEIS2 but this has, to our knowledge, not been experimentally tested so far.
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: Flow Cyt,ICC or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human MEIS1 aa 300-400. The exact sequence is proprietary.

  • Positive control
    • U-87 MG, K562, and HeLa cell lysates
  • General notes



    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab124686 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 47 kDa (predicted molecular weight: 43 kDa).
IP 1/10 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,ICC or IHC-P.
  • Target

    • Function
      Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
    • Tissue specificity
      Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.
    • Involvement in disease
      Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.
    • Sequence similarities
      Belongs to the TALE/MEIS homeobox family.
      Contains 1 homeobox DNA-binding domain.
    • Cellular localization
    • Information by UniProt
    • Database links
    • Alternative names
      • Homeo box protein Meis1 antibody
      • Homeobox protein Meis1 antibody
      • Leukemogenic homolog protein antibody
      • MEIS 1 antibody
      • Meis homeo box 1 antibody
      • Meis homeobox 1 antibody
      • Meis1 antibody
      • Meis1 mouse homolog antibody
      • Meis1 myeloid ecotropic viral integration site 1 homolog antibody
      • Meis1 myeloid ecotropic viral integration site 1 homolog mouse antibody
      • MEIS1 protein antibody
      • MEIS1_HUMAN antibody
      • MGC43380 antibody
      • Myeloid ecotropic viral integration site 1 homolog antibody
      • WUGSC:H NH0444B04.1 antibody
      see all


    • All lanes : Anti-MEIS1 antibody [EPR5781] (ab124686) at 1/10000 dilution

      Lane 1 : U-87 MG cell lysate
      Lane 2 : K562 cell lysate
      Lane 3 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 43 kDa
      Observed band size: 47 kDa (why is the actual band size different from the predicted?)

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD


    ab124686 has not yet been referenced specifically in any publications.

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