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    melanophilin-antibody-ab224373.pdf

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Anti-Melanophilin antibody (ab224373)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Melanophilin antibody (ab224373)

    Key features and details

    • Human polyclonal to Melanophilin
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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    Overview

    • Product name

      Anti-Melanophilin antibody
      See all Melanophilin primary antibodies
    • Description

      Human polyclonal to Melanophilin
    • Host species

      Human
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Recombinant fragment corresponding to Human Melanophilin aa 323-396.
      Sequence:

      ELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVSDIESRIAA LRAAGLTVKPSGKPRRKSNLPIFL


      Database link: Q9BV36-3
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • IHC-P: Human stomach tissue.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.20
      Preservative: 0.02% Sodium azide
      Constituents: 40% Glycerol (glycerin, glycerine), PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Neuroscience
      • Neurotransmission
      • Secretory Vesicles
      • Rabs
      • Signal Transduction
      • Protein Trafficking
      • Vesicle Transport
      • Regulation

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Human IgG - Isotype Control (ab206195)

    Applications

    Our Abpromise guarantee covers the use of ab224373 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
    • Involvement in disease

      Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3) [MIM:609227]. GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations.
    • Sequence similarities

      Contains 1 FYVE-type zinc finger.
      Contains 1 RabBD (Rab-binding) domain.
    • Cellular localization

      Cytoplasm.
    • Target information above from: UniProt accession Q9BV36 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 79083 Human
      • Omim: 606526 Human
      • SwissProt: Q9BV36 Human
      • Unigene: 102406 Human
      • Alternative names

        • 2210418F23Rik antibody
        • 5031433I09Rik antibody
        • AW228792 antibody
        • D1Wsu84e antibody
        • Exophilin 3 antibody
        • Exophilin-3 antibody
        • l(1)-3Rk antibody
        • l1Rk3 antibody
        • Leaden antibody
        • Leaden protein antibody
        • ln antibody
        • Melanophilin antibody
        • MELPH_HUMAN antibody
        • MGC2771 antibody
        • MGC59733 antibody
        • Mlph antibody
        • Slac 2a antibody
        • SlaC2-a antibody
        • Slp homolog lacking C2 domains a antibody
        • Synaptotagmin like protein 2a antibody
        • Synaptotagmin like protein lacking C2 domains A antibody
        • Synaptotagmin-like protein 2a antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Melanophilin antibody (ab224373)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Melanophilin antibody (ab224373)

        Paraffin-embedded human stomach tissue stained for Melanophilin using ab224373 at 1/20 dilution in immunohistochemical analysis.

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab224373? Please let us know so that we can cite the reference in this datasheet.

      ab224373 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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