Anti-Melanophilin antibody (ab224373)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-Melanophilin antibody
See all Melanophilin primary antibodies -
Description
Human polyclonal to Melanophilin -
Host species
Human -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human Melanophilin aa 323-396.
Sequence:ELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVSDIESRIAA LRAAGLTVKPSGKPRRKSNLPIFL
Database link: Q9BV36-3 -
Positive control
- IHC-P: Human stomach tissue.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol, PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab224373 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. -
Involvement in disease
Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3) [MIM:609227]. GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations. -
Sequence similarities
Contains 1 FYVE-type zinc finger.
Contains 1 RabBD (Rab-binding) domain. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 79083 Human
- Omim: 606526 Human
- SwissProt: Q9BV36 Human
- Unigene: 102406 Human
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Alternative names
- 2210418F23Rik antibody
- 5031433I09Rik antibody
- AW228792 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Melanophilin antibody (ab224373)Paraffin-embedded human stomach tissue stained for Melanophilin using ab224373 at 1/20 dilution in immunohistochemical analysis.
Datasheets and documents
References
ab224373 has not yet been referenced specifically in any publications.
