Melatonin, Endogenous hormone agonist at MT1 and MT2 receptors (ab141052)

Overview

  • Product name

    Melatonin, Endogenous hormone agonist at MT1 and MT2 receptors
  • Description

    Endogenous hormone; agonist at MT1 and MT2 receptors
  • Biological description

    Agonist at melatonin MT1 and MT2 receptors. Endogenous hormone important in the control of the circadian rhythm. Wide range of pathophysiological functions including antioxidative and immunomodulatory effects.
  • Purity

    > 99%
  • CAS Number

    73-31-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Pfeffer M  et al. The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors. Chronobiol Int 29:415-29 (2012). Read more (PubMed: 22489607) »
  • Srinivasan V  et al. Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int J Neurosci 119:821-46 (2009). Read more (PubMed: 19326288) »
  • Boutin JA  et al. Molecular tools to study melatonin pathways and actions. Trends Pharmacol Sci 26:412-9 (2005). Read more (PubMed: 15992934) »

Customer reviews and Q&As

Answer

Thank you for contacting us and your interest in the Melatonin compound (ab141052).

We do not carry out biological testing ourselves with this compound but it has been used in several studies with human cell lines, including the following:

MCF-7

http://www.ncbi.nlm.nih.gov/pubmed/3462341

http://cancerres.aacrjournals.org/content/48/21/6121.full.pdf

HepG2

http://www.bmj.sk/2009/11005-02.pdf

SH-SY5Y

http://ijt.sagepub.com/content/25/6/459.abstract

I would suggest the customer search the references within their field of study to determine if a protocol for what they are trying to achieve has been established.

I hope this information has been of help. If I can be of any further assistance, please do not hesitate to let me know.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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