Overview

  • Product name

    Anti-Melatonin Receptor 1B/MTNR1B antibody
    See all Melatonin Receptor 1B/MTNR1B primary antibodies
  • Description

    Rabbit polyclonal to Melatonin Receptor 1B/MTNR1B
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Melatonin Receptor 1B/MTNR1B aa 6-55 (N terminal).
    Sequence:

    SFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDV


    Database link: NP_005950

  • Positive control

    • HepG2 cell lysate
  • General notes

     This product was previously labelled as Melatonin Receptor 1B

     

Properties

Applications

Our Abpromise guarantee covers the use of ab128469 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function

    High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
  • Tissue specificity

    Expressed in retina and less in brain and hippocampus.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • FGQTL2 antibody
    • Mel 1b antibody
    • Mel 1b melatonin receptor antibody
    • Mel 1B R antibody
    • MEL-1B-R antibody
    • Mel1b antibody
    • Mel1b melatonin receptor antibody
    • Mel1b receptor antibody
    • Mel1BR antibody
    • melatonin receptor 1B antibody
    • Melatonin receptor MEL 1B antibody
    • Melatonin receptor MEL1B antibody
    • Melatonin receptor type 1B antibody
    • MT 2 antibody
    • MT 2 melatonin receptor antibody
    • MT2 antibody
    • MT2 melatonin receptor antibody
    • Mtnr 1b antibody
    • Mtnr1b antibody
    • MTR1B_HUMAN antibody
    see all

Images

  • Anti-Melatonin Receptor 1B/MTNR1B antibody (ab128469) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size: 40 kDa



    Gel concentration: 12%

References

This product has been referenced in:

  • Mori F  et al. Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects. Oncotarget 7:20532-48 (2016). WB . Read more (PubMed: 26967561) »
  • Guo P  et al. Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro. Toxicol Sci : (2014). WB . Read more (PubMed: 25159133) »
See all 3 Publications for this product

Customer reviews and Q&As

Application
Western blot
Sample
Human Tissue lysate - whole (Abdominal endometriotic lesion)
Gel Running Conditions
Reduced Denaturing (12% gel)
Loading amount
15 µg
Specification
Abdominal endometriotic lesion
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

Abcam user community

Verified customer

Submitted Mar 21 2017

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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