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  1. Link

    melatonin-receptor-1bmtnr1b-antibody-n-terminal-ab229544.pdf

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Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal (ab229544)

  • Datasheet
  • SDS
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Western blot - Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal (ab229544)
  • Western blot - Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal (ab229544)

Key features and details

  • Rabbit polyclonal to Melatonin Receptor 1B/MTNR1B - N-terminal
  • Suitable for: WB
  • Reacts with: Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal
    See all Melatonin Receptor 1B/MTNR1B primary antibodies
  • Description

    Rabbit polyclonal to Melatonin Receptor 1B/MTNR1B - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Melatonin Receptor 1B/MTNR1B (N terminal). The exact sequence is proprietary. Conjugated to a carrier protein.
    Database link: P49286

  • Positive control

    • WB: K562, THP-1, U-87 MG, SK-N-SH, IMR32 and SK-N-AS whole cell lysates.
  • General notes

     This product was previously labelled as Melatonin Receptor 1B

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.025% Proclin 300
    Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • More GPCR
    • Neuroscience
    • Neurology process
    • Metabolism

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • SK N SH whole cell lysate (ab3956)
    • K562 whole cell lysate (ab7911)
    • THP1 whole cell lysate (ab7913)

Applications

Our Abpromise guarantee covers the use of ab229544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.

Target

  • Function

    High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
  • Tissue specificity

    Expressed in retina and less in brain and hippocampus.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession P49286 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 4544 Human
    • Omim: 600804 Human
    • SwissProt: P49286 Human
    • Unigene: 569039 Human
    • Alternative names

      • FGQTL2 antibody
      • Mel 1b antibody
      • Mel 1b melatonin receptor antibody
      • Mel 1B R antibody
      • MEL-1B-R antibody
      • Mel1b antibody
      • Mel1b melatonin receptor antibody
      • Mel1b receptor antibody
      • Mel1BR antibody
      • melatonin receptor 1B antibody
      • Melatonin receptor MEL 1B antibody
      • Melatonin receptor MEL1B antibody
      • Melatonin receptor type 1B antibody
      • MT 2 antibody
      • MT 2 melatonin receptor antibody
      • MT2 antibody
      • MT2 melatonin receptor antibody
      • Mtnr 1b antibody
      • Mtnr1b antibody
      • MTR1B_HUMAN antibody
      see all

    Images

    • Western blot - Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal (ab229544)
      Western blot - Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal (ab229544)
      All lanes : Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal (ab229544) at 1/1000 dilution

      Lane 1 : K562 (human chronic myelogenous leukemia cell line from bone marrow) whole cell lysate
      Lane 2 : THP-1 (human monocytic leukemia cell line) whole cell lysate

      Lysates/proteins at 30 µg per lane.

      Predicted band size: 40 kDa



      12% SDS-PAGE gel.

    • Western blot - Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal (ab229544)
      Western blot - Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal (ab229544)
      All lanes : Anti-Melatonin Receptor 1B/MTNR1B antibody - N-terminal (ab229544) at 1/1000 dilution

      Lane 1 : U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell lysate
      Lane 2 : SK-N-SH (human neuroblastoma cell line) whole cell lysate
      Lane 3 : IMR32 whole cell lysate
      Lane 4 : SK-N-AS whole cell lysate

      Lysates/proteins at 30 µg per lane.

      Predicted band size: 40 kDa



      12% SDS-PAGE gel.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (1)

    Publishing research using ab229544? Please let us know so that we can cite the reference in this datasheet.

    ab229544 has been referenced in 1 publication.

    • Jablonska K  et al. Prognostic Impact of Melatonin Receptors MT1 and MT2 in Non-Small Cell Lung Cancer (NSCLC). Cancers (Basel) 11:N/A (2019). PubMed: 31319607

    Customer reviews and Q&As

    Show All Reviews Q&A
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