Overview

  • Product name

    Mensacarcin, cytotoxic agent
  • Description

    Potent cytotoxic agent
  • Biological description

    Potent cytotoxic agent. Putative antitumor agent. Antibiotic. Shows similarly potent cytostatic and cytotoxic effects as doxorubicin (ab120629).
  • Purity

    > 98%
  • CAS Number

    808750-39-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,2S,3S,4S,4aS,9aS,10S)-1,3,4-Trihydroxy-5,10-dimethoxy-2-methyl-3-{[(2R,3S)-3-methyloxiran-2-yl]carbonyl}-1,2,3,4-tetrahydro-4a,9a-epoxyanthracen-9(10H)-one
  • Molecular weight

    420.41
  • Molecular formula

    C21H24O9
  • PubChem identifier

    403671
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H]1[C@H]([C@@]23C(=O)C4=C([C@@H]([C@@]2(O3)[C@H]([C@@]1(C(=O)[C@H]5[C@@H](O5)C)O)O)OC)C(=CC=C4)OC)O
  • Source

    Streptomyces bottropensis

  • Research areas

References

This product has been referenced in:

  • Maier S  et al. Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8. Chembiochem 15:749-56 (2014). Read more (PubMed: 24554499) »
  • Yan X  et al. Cloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis. Chembiochem 13:224-30 (2012). Read more (PubMed: 22162248) »
  • Tietze LF  et al. Towards a total synthesis of the new anticancer agent mensacarcin: synthesis of the carbocyclic core. Chemistry 10:5233-42 (2004). Read more (PubMed: 15372645) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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