Key features and details
- Rabbit polyclonal to Meprin beta
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Meprin beta antibody
See all Meprin beta primary antibodies
DescriptionRabbit polyclonal to Meprin beta
SpecificityMeprin beta antibody Math Domain recognizes meprin beta but not alpha subunits.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)(Peptide available as ab44829.)
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.05% Sodium azide
Constituent: 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPeptide-affinity purified.
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab42743 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionMembrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.
Tissue specificityThe major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
Sequence similaritiesBelongs to the peptidase M12A family.
Contains 1 EGF-like domain.
Contains 1 MAM domain.
Contains 1 MATH domain.
modificationsN-glycosylated; contains high mannose and/or complex biantennary structures.
O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to be specific to human.
Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues.
Cellular localizationCell membrane. Secreted. Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.
- Information by UniProt
- Endopeptidase 2 antibody
- Endopeptidase-2 antibody
- kinase splitting membranal proteinase antibody
ab42743 has been referenced in 1 publication.
- Livingston MJ et al. Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. Autophagy 12:976-98 (2016). PubMed: 27123926