Mertansine (DM1 Compound), microtubule-targeted cytotoxic agent (ab146096)

Overview

  • Product name

    Mertansine (DM1 Compound), microtubule-targeted cytotoxic agent
  • Description

    Potent microtubule-targeted cytotoxic agent
  • Alternative names

    • DM1 Compound
  • Biological description

    Potent microtubule-targeted cytotoxic agent. Induces mitotic arrest. Inhibits microtubule polymerization. Shows antitumor effects in vivo.
  • CAS Number

    139504-50-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine

  • Molecular weight

    738.29
  • Molecular formula

    C35H48ClN3O10S
  • PubChem identifier

    71301226
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Slightly soluble in Chloroform and Methanol. 

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C\C=C(\CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@H]([C@]4(C1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)/C)OC)(NC(=O)O2)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gurtner K  et al. Combined treatment of the immunoconjugate bivatuzumab mertansine and fractionated irradiation improves local tumour control in vivo. Radiother Oncol 102:444-9 (2012). Read more (PubMed: 22100655) »
  • Xie H  et al. Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice. J Pharmacol Exp Ther 308:1073-82 (2004). Read more (PubMed: 14634038) »
  • Platt VM & Szoka FC Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol Pharm 5:474-86 (0). Read more (PubMed: 18547053) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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