Key features and details
- Rabbit polyclonal to MERTK
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MERTK antibody
See all MERTK primary antibodies
DescriptionRabbit polyclonal to MERTK
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Chimpanzee, Rhesus monkey, Orangutan
Synthetic peptide corresponding to a region between residues 200 and 250 of human MERTK.
- U937 cell whole cell lysate
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab70693 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/5000 - 1/20000. Detects a band of approximately 120 kDa (predicted molecular weight: 110 kDa).|
FunctionIn case of filovirus infection, seems to function as a cell entry factor.
Tissue specificityNot expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
Involvement in diseaseDefects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
- Information by UniProt
- c MER antibody
- c mer proto oncogene tyrosine kinase antibody
- c-mer antibody
Anti-MERTK antibody (ab70693) at 0.1 µg/ml + U937 cell lysate at 50 µg
Predicted band size: 110 kDa
Observed band size: 120 kDa why is the actual band size different from the predicted?
ab70693 has been referenced in 1 publication.
- Jiang J et al. Crucial roles for protein kinase C isoforms in tumor-specific killing by apoptin. Cancer Res 70:7242-52 (2010). WB ; Human . PubMed: 20719884