Overview

  • Product name

    Anti-MERTK antibody [NO.H1B0]
    See all MERTK primary antibodies
  • Description

    Rabbit monoclonal [NO.H1B0] to MERTK
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human MERTK aa 28-45.
    Sequence:

    EAKPYPLFPGPFPGSLQT


    Database link: Q12866

  • Positive control

    • WB: HEK-293T cell extract. IHC-P: Human tonsil tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab238516 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 110 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function

    In case of filovirus infection, seems to function as a cell entry factor.
  • Tissue specificity

    Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
  • Involvement in disease

    Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • c MER antibody
    • c mer proto oncogene tyrosine kinase antibody
    • c-mer antibody
    • cMER antibody
    • cmer protooncogene tyrosine kinase antibody
    • Eyk antibody
    • MER antibody
    • MER receptor tyrosine kinase antibody
    • MERK antibody
    • MERPEN antibody
    • Mertk antibody
    • MERTK c-mer proto-oncogene tyrosine kinase antibody
    • MERTK_HUMAN antibody
    • MGC133349 antibody
    • nmf12 antibody
    • Nyk antibody
    • Proto oncogene tyrosine protein kinase MER antibody
    • Proto oncogene tyrosine protein kinase MER precursor antibody
    • Proto-oncogene c-Mer antibody
    • Receptor tyrosine kinase MerTK antibody
    • RP38 antibody
    • STK kinase antibody
    • Tyrosine-protein kinase Mer antibody
    see all

Images

  • Anti-MERTK antibody [NO.H1B0] (ab238516) at 1/500 dilution + HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell extract at 25 µg

    Secondary
    HRP Goat Anti-Rabbit IgG (H+L) at 1/10000 dilution

    Predicted band size: 110 kDa

  • Paraffin-embedded human tonsil tissue stained for MERTK using ab238516 at 1/100 dilution in immunohistochemical analysis.

References

ab238516 has not yet been referenced specifically in any publications.

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