Anti-MESDC2 antibody [C22F5] (ab230785)

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Overview

  • Product name

    Anti-MESDC2 antibody [C22F5]

  • Description

    Rabbit monoclonal [C22F5] to MESDC2

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Monkey

  • Immunogen

    Recombinant full length protein corresponding to Human MESDC2.
    Database link: Q14696-1

  • Positive control

    • IHC-P: Human placenta and pancreas tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab230785 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100.

Target

  • Function

    Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.

  • Sequence similarities

    Belongs to the MESD family.

  • Domain

    The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.

  • Cellular localization

    Endoplasmic reticulum.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • BOCA antibody
    • KIAA0081 antibody
    • LDLR chaperone MESD antibody
    • MESD antibody
    • MESD_HUMAN antibody
    • MESDC 2 antibody
    • mesdc2 antibody
    • Mesoderm development candidate 2 antibody
    • Mesoderm development protein antibody
    • Renal carcinoma antigen NY REN 61 antibody
    • Renal carcinoma antigen NY-REN-61 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)

    Formalin-fixed, paraffin-embedded human placenta tissue stained for MESDC2 using ab230785 at 1/100 dilution in immunohistochemical analysis.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)

    Formalin-fixed, paraffin-embedded human pancreas tissue stained for MESDC2 using ab230785 at 1/100 dilution in immunohistochemical analysis.

References

ab230785 has not yet been referenced specifically in any publications.

Publishing research using ab230785? Please let us know so that we can cite the reference in this datasheet.

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