Anti-MESDC2 antibody [C22F5] (ab230785)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)](https://www.abcam.com/ps/products/230/ab230785/Images/ab230785-299018-ab2307851.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)")
Key features and details
- Rabbit monoclonal [C22F5] to MESDC2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-MESDC2 antibody [C22F5] -
Description
Rabbit monoclonal [C22F5] to MESDC2 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Monkey
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Immunogen
Recombinant full length protein corresponding to Human MESDC2.
Database link: Q14696-1 -
Positive control
- IHC-P: Human placenta and pancreas tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.50
Preservative: 0.02% Sodium azide
Constituents: 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine), 0.01% BSA, 0.26% HEPES -
Concentration information loading... -
Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
C22F5 -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab230785 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
1/100.
|
| Notes |
|---|
|
IHC-P
1/100. |
Target
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Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. -
Sequence similarities
Belongs to the MESD family. -
Domain
The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding. -
Cellular localization
Endoplasmic reticulum. - Information by UniProt
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Database links
- Entrez Gene: 23184 Human
- Entrez Gene: 67943 Mouse
- Entrez Gene: 308796 Rat
- Omim: 607783 Human
- SwissProt: Q14696 Human
- SwissProt: Q9ERE7 Mouse
- SwissProt: Q5U2R7 Rat
- Unigene: 578450 Human
see all -
Alternative names
- BOCA antibody
- KIAA0081 antibody
- LDLR chaperone MESD antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)
Formalin-fixed, paraffin-embedded human placenta tissue stained for MESDC2 using ab230785 at 1/100 dilution in immunohistochemical analysis.
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)](https://www.abcam.com/ps/products/230/ab230785/Images/ab230785-299017-ab2307852.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)Formalin-fixed, paraffin-embedded human pancreas tissue stained for MESDC2 using ab230785 at 1/100 dilution in immunohistochemical analysis.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab230785 has not yet been referenced specifically in any publications.
