Overview

  • Product name

    Anti-MESDC2 antibody [C22F5]
  • Description

    Rabbit monoclonal [C22F5] to MESDC2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Monkey
  • Immunogen

    Recombinant full length protein corresponding to Human MESDC2.
    Database link: Q14696-1

  • Positive control

    • IHC-P: Human placenta and pancreas tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab230785 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100.

Target

  • Function

    Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
  • Sequence similarities

    Belongs to the MESD family.
  • Domain

    The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
  • Cellular localization

    Endoplasmic reticulum.
  • Information by UniProt
  • Database links

  • Alternative names

    • BOCA antibody
    • KIAA0081 antibody
    • LDLR chaperone MESD antibody
    • MESD antibody
    • MESD_HUMAN antibody
    • MESDC 2 antibody
    • mesdc2 antibody
    • Mesoderm development candidate 2 antibody
    • Mesoderm development protein antibody
    • Renal carcinoma antigen NY REN 61 antibody
    • Renal carcinoma antigen NY-REN-61 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human placenta tissue stained for MESDC2 using ab230785 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human pancreas tissue stained for MESDC2 using ab230785 at 1/100 dilution in immunohistochemical analysis.

References

ab230785 has not yet been referenced specifically in any publications.

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