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    mesdc2-antibody-c22f5-ab230785.pdf

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Stem Cells Lineage Markers Mesoderm
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Anti-MESDC2 antibody [C22F5] (ab230785)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)

Key features and details

  • Rabbit monoclonal [C22F5] to MESDC2
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Recombinant Human MESDC2 protein (ab104671)
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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-MESDC2 antibody [C22F5]
  • Description

    Rabbit monoclonal [C22F5] to MESDC2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Monkey
  • Immunogen

    Recombinant full length protein corresponding to Human MESDC2.
    Database link: Q14696-1

  • Positive control

    • IHC-P: Human placenta and pancreas tissues.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.50
    Preservative: 0.02% Sodium azide
    Constituents: 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine), 0.01% BSA, 0.26% HEPES
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    C22F5
  • Isotype

    IgG
  • Research areas

    • Stem Cells
    • Lineage Markers
    • Mesoderm
    • Stem Cells
    • Mesenchymal Stem Cells
    • Intracellular
    • Developmental Biology
    • Lineage specification
    • Mesoderm

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Recombinant Protein

    • Recombinant Human MESDC2 protein (ab104671)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab230785 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
1/100.
Notes
IHC-P
1/100.

Target

  • Function

    Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
  • Sequence similarities

    Belongs to the MESD family.
  • Domain

    The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
  • Cellular localization

    Endoplasmic reticulum.
  • Target information above from: UniProt accession Q14696 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 23184 Human
    • Entrez Gene: 67943 Mouse
    • Entrez Gene: 308796 Rat
    • Omim: 607783 Human
    • SwissProt: Q14696 Human
    • SwissProt: Q9ERE7 Mouse
    • SwissProt: Q5U2R7 Rat
    • Unigene: 578450 Human
    • Unigene: 732380 Human
    • Unigene: 117365 Mouse
    • Unigene: 41045 Rat
    see all
  • Alternative names

    • BOCA antibody
    • KIAA0081 antibody
    • LDLR chaperone MESD antibody
    • MESD antibody
    • MESD_HUMAN antibody
    • MESDC 2 antibody
    • mesdc2 antibody
    • Mesoderm development candidate 2 antibody
    • Mesoderm development protein antibody
    • Renal carcinoma antigen NY REN 61 antibody
    • Renal carcinoma antigen NY-REN-61 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)

    Formalin-fixed, paraffin-embedded human placenta tissue stained for MESDC2 using ab230785 at 1/100 dilution in immunohistochemical analysis.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MESDC2 antibody [C22F5] (ab230785)

    Formalin-fixed, paraffin-embedded human pancreas tissue stained for MESDC2 using ab230785 at 1/100 dilution in immunohistochemical analysis.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (0)

Publishing research using ab230785? Please let us know so that we can cite the reference in this datasheet.

ab230785 has not yet been referenced specifically in any publications.

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