Key features and details
- Rabbit monoclonal [C22F5] to MESDC2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MESDC2 antibody [C22F5]
DescriptionRabbit monoclonal [C22F5] to MESDC2
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Monkey
Recombinant full length protein corresponding to Human MESDC2.
Database link: Q14696-1
- IHC-P: Human placenta and pancreas tissues.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.50
Preservative: 0.02% Sodium azide
Constituents: 0.87% Sodium chloride, 50% Glycerol, 0.01% BSA, 0.26% HEPES
Concentration information loading...
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab230785 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionChaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
Sequence similaritiesBelongs to the MESD family.
DomainThe chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
Cellular localizationEndoplasmic reticulum.
- Information by UniProt
- BOCA antibody
- KIAA0081 antibody
- LDLR chaperone MESD antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab230785 has not yet been referenced specifically in any publications.