Recombinant
RabMAb

Recombinant Anti-Mesothelin antibody [EPR19025-45] (ab222662)

Overview

  • Product name

    Anti-Mesothelin antibody [EPR19025-45]
    See all Mesothelin primary antibodies
  • Description

    Rabbit monoclonal [EPR19025-45] to Mesothelin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: Sandwich ELISAmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • General notes

    Anti-Mesothelin antibody is used in our 90-minute Human Mesothelin ELISA Kit (ab216168), and is available in a Matched Antibody Pair Kit (ab216051).

Properties

Applications

Our Abpromise guarantee covers the use of ab222662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA Use at an assay dependent concentration.

Target

  • Function

    Membrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
  • Tissue specificity

    Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
  • Involvement in disease

    Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
  • Sequence similarities

    Belongs to the mesothelin family.
  • Post-translational
    modifications

    Both MPF and the cleaved form of mesothelin are N-glycosylated.
    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • Cellular localization

    Secreted and Cell membrane. Golgi apparatus.
  • Information by UniProt
  • Database links

  • Alternative names

    • CAK 1 antibody
    • CAK1 antibody
    • CAK1 antigen antibody
    • cleaved form antibody
    • Megakaryocyte potentiating factor antibody
    • Mesothelin antibody
    • Mesothelin isoform 1 precursor antibody
    • MPF antibody
    • Msln antibody
    • MSLN_HUMAN antibody
    • Pre pro megakaryocyte potentiating factor antibody
    • Pre-pro-megakaryocyte-potentiating factor antibody
    • SMR antibody
    • SMRP antibody
    • Soluble MPF mesothelin related protein antibody
    see all

Images

  • Example of human Mesothelin standard curve in 1X Cell Extraction Buffer PTR using recombinant Mesothelin RabMAb antibody (ab222662) and a recombinant monoclonal antibody. Background-subtracted values (mean +/- SD) are graphed.

    For a matched antibody pair set, see Human Mesothelin Matched Antibody Pair Kit (ab216051).

    For a complete ELISA kit, see Human Mesothelin ELISA kit (ab216168).

References

ab222662 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab222662.
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