Key features and details
- Mouse monoclonal [1B3F9] to Mesp2
- Suitable for: WB, ELISA
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-Mesp2 antibody [1B3F9]
See all Mesp2 primary antibodies
DescriptionMouse monoclonal [1B3F9] to Mesp2
Tested applicationsSuitable for: WB, ELISAmore details
Species reactivityReacts with: Human
- Human Mesp2 recombinant protein; Mesp2 (amino acids 37-94)-hIgGFc transfected HEK293 cell lysate
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.05% Sodium azide
Constituent: 99% PBS
Contains 0.5% protein stabilizer.
Concentration information loading...
PurityProtein G purified
Purification notesPurified from tissue culture supernatant.
Our Abpromise guarantee covers the use of ab166702 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 42 kDa.|
FunctionTranscription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
Involvement in diseaseDefects in MESP2 are the cause of spondylocostal dysostosis type 2 (SCDO2) [MIM:608681]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
Sequence similaritiesContains 1 bHLH (basic helix-loop-helix) domain.
modificationsDegraded by the proteasome.
- Information by UniProt
- Basic helix loop helix protein MESP 2 antibody
- Basic helix loop helix protein MESP2 antibody
- BHLH protein MesP2 antibody
Anti-Mesp2 antibody [1B3F9] (ab166702) at 1/500 dilution + Human Mesp2 recombinant protein
Predicted band size: 42 kDa
All lanes : Anti-Mesp2 antibody [1B3F9] (ab166702) at 1/500 dilution
Lane 1 : HEK293 cell lysate
Lane 2 : Mesp2 (amino acids 37-94)-hIgGFc transfected HEK293 cell lysate
Predicted band size: 42 kDa
ELISA using ab166702 at a 1/10000 dilution.
Red: Control Antigen (100 ng)
Purple: Antigen (10 ng)
Green: Antigen (50 ng)
Blue: Antigen (100 ng)
ab166702 has not yet been referenced specifically in any publications.