Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal (ab188750)
Key features and details
- Rabbit polyclonal to Metabotropic Glutamate Receptor 3/MGLUR3 - N-terminal
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
-
Product name
Anti-Metabotropic Glutamate Receptor 3/MGLUR3 antibody - N-terminal
See all Metabotropic Glutamate Receptor 3/MGLUR3 primary antibodies -
Description
Rabbit polyclonal to Metabotropic Glutamate Receptor 3/MGLUR3 - N-terminal -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins. -
Tested applications
Suitable for: IHC-P, ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Horse, Cow, Pig, Monkey, Gorilla, Common marmoset, Orangutan -
Immunogen
Synthetic peptide within Human Metabotropic Glutamate Receptor 3/MGLUR3 (N terminal). The exact sequence is proprietary. Synthetic 16 amino acid peptide from N-terminal extracellular domain of Human Metabotropic Glutamate Receptor 3/MGLUR3 (NP_000831.2)
Database link: Q14832 -
Positive control
- Human brain, coroid plexus tissue; HEK293 Human embryonic kidney cells transfected with Metabotropic Glutamate Receptor 3/MGLUR3.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab188750 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
|
|
ICC/IF |
Use a concentration of 5 - 15 µg/ml.
|
Notes |
---|
IHC-P
Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
ICC/IF
Use a concentration of 5 - 15 µg/ml. |
Target
-
Function
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. -
Sequence similarities
Belongs to the G-protein coupled receptor 3 family. -
Cellular localization
Cell membrane. - Information by UniProt
-
Database links
- Entrez Gene: 2913 Human
- Entrez Gene: 108069 Mouse
- Entrez Gene: 24416 Rat
- Omim: 601115 Human
- SwissProt: Q14832 Human
- SwissProt: Q9QYS2 Mouse
- SwissProt: Q5RAL3 Orangutan
- SwissProt: P31422 Rat
see all -
Alternative names
- GLUR3 antibody
- Glutamate metabotropic receptor 3 antibody
- Glutamate receptor metabotropic 3 antibody
see all
Images
-
Immunohistochemical analysis of Human Kidney tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.
-
Immunocytochemical analysis of HEK293 tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.
-
Immunohistochemical analysis of Human Testies tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.
-
Immunohistochemical analysis of Human skin melanoma tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.
-
Immunohistochemical analysis of Human brain, Glioblastoma tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10 μg/ml.
-
Immunocytochemistry of HEK293 Human embryonic kidney cells transfected with Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 10ug/ml.
-
Immunohistochemical analysis of Human brain, coroid plexus tissue labeling Metabotropic Glutamate Receptor 3/MGLUR3 using ab188750 at 38 μg/ml.
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (5)
ab188750 has been referenced in 5 publications.
- Maier JP et al. Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma. Cell Death Dis 12:723 (2021). PubMed: 34290229
- Klotz L et al. Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses. FASEB J 33:13734-13746 (2019). PubMed: 31585509
- García-Bea A et al. A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding. J Psychopharmacol 31:1519-1526 (2017). WB . PubMed: 28655286
- Yao L et al. Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Hypothalamic Neurones Provides Developmental Insights into Genetic Loci for Body Weight Regulation. J Neuroendocrinol 29:N/A (2017). PubMed: 28071834
- García-Bea A et al. Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study. Schizophr Res N/A:N/A (2016). WB ; Mouse . PubMed: 27130562