Anti-Metallothionein antibody [UC1MT] (ab12228)

Mouse monoclonal Metallothionein antibody [UC1MT]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Rabbit, Horse, Dog, Human, Mummichug fish. Cited in 32 publication(s).

Publishing research using ab12228? Please let us know so that we can cite the reference in this datasheet.

ab12228 has been referenced in 34 publications.

  • Kawahara B  et al. Carbon monoxide sensitizes cisplatin-resistant ovarian cancer cell lines toward cisplatin via attenuation of levels of glutathione and nuclear metallothionein. J Inorg Biochem 191:29-39 (2019). PubMed: 30458366
  • Rodríguez-Menéndez S  et al. The Zinc-Metallothionein Redox System Reduces Oxidative Stress in Retinal Pigment Epithelial Cells. Nutrients 10:N/A (2018). PubMed: 30513827
  • Zou X  et al. Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin-induced model of liver injury. Int J Mol Med 42:2020-2030 (2018). PubMed: 30066834
  • Lu J  et al. Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm. Stem Cell Res 28:48-55 (2018). ICC/IF ; Human . PubMed: 29427839
  • Borchard S  et al. The exceptional sensitivity of brain mitochondria to copper. Toxicol In Vitro 51:11-22 (2018). PubMed: 29715505
  • Zeng JD  et al. MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma. J Cancer 9:2807-2816 (2018). PubMed: 30123349
  • Sullivan B  et al. On the nature of the Cu-rich aggregates in brain astrocytes. Redox Biol 11:231-239 (2017). PubMed: 28012438
  • Lin Z  et al. Decreased long non-coding RNA MTM contributes to gastric cancer cell migration and invasion via modulating MT1F. Oncotarget 8:97371-97383 (2017). PubMed: 29228617
  • Kadota Y  et al. Metallothioneins regulate the adipogenic differentiation of 3T3-L1 cells via the insulin signaling pathway. PLoS One 12:e0176070 (2017). ICC/IF . PubMed: 28426713
  • Tunçdemir M  et al. Investigation of lipid peroxidation and antiapoptotic effects of zinc aganist liver damage in diabetic rats. Hum Exp Toxicol N/A:N/A (2016). PubMed: 27609014
  • Wang M  et al. Time-dependent toxicity of cadmium telluride quantum dots on liver and kidneys in mice: histopathological changes with elevated free cadmium ions and hydroxyl radicals. Int J Nanomedicine 11:2319-28 (2016). IHC . PubMed: 27307732
  • Sridharan S  et al. Metallothionein Expression in Dogs With Chronic Hepatitis and Its Correlation With Hepatic Fibrosis, Inflammation, and Ki-67 Expression. Vet Pathol 52:1127-33 (2015). PubMed: 26077783
  • Wang N  et al. Overexpression of HIF-1a, metallothionein and SLUG is associated with high TNM stage and lymph node metastasis in papillary thyroid carcinoma. Int J Clin Exp Pathol 7:322-30 (2014). IHC ; Human . PubMed: 24427353
  • Simon BR  et al. The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium. Toxicol Rep 1:231-242 (2014). PubMed: 25126521
  • Zhang D  et al. Zinc supplementation protects against cadmium accumulation and cytotoxicity in Madin-Darby bovine kidney cells. PLoS One 9:e103427 (2014). WB, ICC/IF ; Dog . PubMed: 25105504
  • Baba H  et al. The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression. Mod Pathol 26:1228-34 (2013). IHC-P ; Human . PubMed: 23558578
  • Habel N  et al. Zinc chelation: a metallothionein 2A's mechanism of action involved in osteosarcoma cell death and chemotherapy resistance. Cell Death Dis 4:e874 (2013). WB ; Human . PubMed: 24157868
  • Dai S  et al. Quantification of metallothionein on the liver and kidney of rats by subchronic lead and cadmium in combination. Environ Toxicol Pharmacol 36:1207-16 (2013). IHC-P ; Rat . PubMed: 24184865
  • Hoelscher M  et al. SELDI-TOF analysis of glioblastoma cyst fluid is an approach for assessing cellular protein expression. Neurol Res 35:993-1001 (2013). IHC-P ; Human . PubMed: 24225180
  • Pushkar Y  et al. Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone. Aging Cell 12:823-32 (2013). IHC-Fr ; Rat . PubMed: 23738916
  • Park J  et al. Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours. EMBO Mol Med 5:935-48 (2013). IHC-P . PubMed: 23629957
  • Yan DW  et al. Downregulation of metallothionein 1F, a putative oncosuppressor, by loss of heterozygosity in colon cancer tissue. Biochim Biophys Acta 1822:918-26 (2012). PubMed: 22426038
  • Martano M  et al. Metallothionein expression in canine cutaneous apocrine gland tumors. Anticancer Res 32:747-52 (2012). IHC-P, WB ; Dog . PubMed: 22399587
  • Alvarez L  et al. The Stoichiometric Transition from Zn6Cu1-Metallothionein to Zn7-Metallothionein Underlies the Up-regulation of Metallothionein (MT) Expression: QUANTITATIVE ANALYSIS OF MT-METAL LOAD IN EYE CELLS. J Biol Chem 287:28456-69 (2012). IHC-P ; Human . PubMed: 22722935
  • Abdullah M  et al. Pulmonary haptoglobin and CD163 are functional immunoregulatory elements in the human lung. Respiration 83:61-73 (2012). ICC/IF ; Human . PubMed: 21860221
  • Goh SH  et al. eIF3m expression influences the regulation of tumorigenesis-related genes in human colon cancer. Oncogene 30:398-409 (2011). WB ; Human . PubMed: 20838379
  • Mathis JM  et al. Genetic Incorporation of Human Metallothionein into the Adenovirus Protein IX for Non-Invasive SPECT Imaging. PLoS One 6:e16792 (2011). WB ; Human . PubMed: 21347423
  • Peterson SM  et al. Global gene expression analysis reveals dynamic and developmental stage-dependent enrichment of lead-induced neurological gene alterations. Environ Health Perspect 119:615-21 (2011). PubMed: 21147602
  • Wang Q  et al. Analysis of metallotionein expression and antioxidant enzyme activities in Meretrix meretrix larvae under sublethal cadmium exposure. Aquat Toxicol 100:321-8 (2010). IHC-Fr . PubMed: 20869127
  • Wang L  et al. Effects of lead and/or cadmium on the expression of metallothionein in the kidney of rats. Biol Trace Elem Res 129:190-9 (2009). IHC-P ; Rat . PubMed: 19096765
  • Gonçalves I  et al. Transthyretin interacts with metallothionein 2. Biochemistry 47:2244-51 (2008). IHC-P ; Rat . PubMed: 18237193
  • Oakley MS  et al. Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. Infect Immun 76:4518-29 (2008). PubMed: 18644885
  • Lee WW  et al. Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling. Rejuvenation Res 11:1001-11 (2008). Flow Cyt ; Human . PubMed: 19072254
  • Girnun GD  et al. Synergy between PPARgamma ligands and platinum-based drugs in cancer. Cancer Cell 11:395-406 (2007). PubMed: 17482130

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