Anti-Metallothionein antibody [UC1MT] (ab12228)

Mouse monoclonal Metallothionein antibody [UC1MT]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Rabbit, Horse, Dog, Human, Mummichug fish. Cited in 32 publication(s).

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ab12228 has been referenced in 34 publications.

  • Kawahara B  et al. Carbon monoxide sensitizes cisplatin-resistant ovarian cancer cell lines toward cisplatin via attenuation of levels of glutathione and nuclear metallothionein. J Inorg Biochem 191:29-39 (2019). PubMed: 30458366
  • Rodríguez-Menéndez S  et al. The Zinc-Metallothionein Redox System Reduces Oxidative Stress in Retinal Pigment Epithelial Cells. Nutrients 10:N/A (2018). PubMed: 30513827
  • Zou X  et al. Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin-induced model of liver injury. Int J Mol Med 42:2020-2030 (2018). PubMed: 30066834
  • Lu J  et al. Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm. Stem Cell Res 28:48-55 (2018). ICC/IF ; Human . PubMed: 29427839
  • Borchard S  et al. The exceptional sensitivity of brain mitochondria to copper. Toxicol In Vitro 51:11-22 (2018). PubMed: 29715505
  • Zeng JD  et al. MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma. J Cancer 9:2807-2816 (2018). PubMed: 30123349
  • Sullivan B  et al. On the nature of the Cu-rich aggregates in brain astrocytes. Redox Biol 11:231-239 (2017). PubMed: 28012438
  • Lin Z  et al. Decreased long non-coding RNA MTM contributes to gastric cancer cell migration and invasion via modulating MT1F. Oncotarget 8:97371-97383 (2017). PubMed: 29228617
  • Kadota Y  et al. Metallothioneins regulate the adipogenic differentiation of 3T3-L1 cells via the insulin signaling pathway. PLoS One 12:e0176070 (2017). ICC/IF . PubMed: 28426713
  • Tunçdemir M  et al. Investigation of lipid peroxidation and antiapoptotic effects of zinc aganist liver damage in diabetic rats. Hum Exp Toxicol N/A:N/A (2016). PubMed: 27609014
  • Wang M  et al. Time-dependent toxicity of cadmium telluride quantum dots on liver and kidneys in mice: histopathological changes with elevated free cadmium ions and hydroxyl radicals. Int J Nanomedicine 11:2319-28 (2016). IHC . PubMed: 27307732
  • Sridharan S  et al. Metallothionein Expression in Dogs With Chronic Hepatitis and Its Correlation With Hepatic Fibrosis, Inflammation, and Ki-67 Expression. Vet Pathol 52:1127-33 (2015). PubMed: 26077783
  • Wang N  et al. Overexpression of HIF-1a, metallothionein and SLUG is associated with high TNM stage and lymph node metastasis in papillary thyroid carcinoma. Int J Clin Exp Pathol 7:322-30 (2014). IHC ; Human . PubMed: 24427353
  • Simon BR  et al. The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium. Toxicol Rep 1:231-242 (2014). PubMed: 25126521
  • Zhang D  et al. Zinc supplementation protects against cadmium accumulation and cytotoxicity in Madin-Darby bovine kidney cells. PLoS One 9:e103427 (2014). WB, ICC/IF ; Dog . PubMed: 25105504
  • Baba H  et al. The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression. Mod Pathol 26:1228-34 (2013). IHC-P ; Human . PubMed: 23558578
  • Habel N  et al. Zinc chelation: a metallothionein 2A's mechanism of action involved in osteosarcoma cell death and chemotherapy resistance. Cell Death Dis 4:e874 (2013). WB ; Human . PubMed: 24157868
  • Dai S  et al. Quantification of metallothionein on the liver and kidney of rats by subchronic lead and cadmium in combination. Environ Toxicol Pharmacol 36:1207-16 (2013). IHC-P ; Rat . PubMed: 24184865
  • Hoelscher M  et al. SELDI-TOF analysis of glioblastoma cyst fluid is an approach for assessing cellular protein expression. Neurol Res 35:993-1001 (2013). IHC-P ; Human . PubMed: 24225180
  • Pushkar Y  et al. Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone. Aging Cell 12:823-32 (2013). IHC-Fr ; Rat . PubMed: 23738916
  • Park J  et al. Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours. EMBO Mol Med 5:935-48 (2013). IHC-P . PubMed: 23629957
  • Yan DW  et al. Downregulation of metallothionein 1F, a putative oncosuppressor, by loss of heterozygosity in colon cancer tissue. Biochim Biophys Acta 1822:918-26 (2012). PubMed: 22426038
  • Martano M  et al. Metallothionein expression in canine cutaneous apocrine gland tumors. Anticancer Res 32:747-52 (2012). IHC-P, WB ; Dog . PubMed: 22399587
  • Alvarez L  et al. The Stoichiometric Transition from Zn6Cu1-Metallothionein to Zn7-Metallothionein Underlies the Up-regulation of Metallothionein (MT) Expression: QUANTITATIVE ANALYSIS OF MT-METAL LOAD IN EYE CELLS. J Biol Chem 287:28456-69 (2012). IHC-P ; Human . PubMed: 22722935
  • Abdullah M  et al. Pulmonary haptoglobin and CD163 are functional immunoregulatory elements in the human lung. Respiration 83:61-73 (2012). ICC/IF ; Human . PubMed: 21860221
  • Goh SH  et al. eIF3m expression influences the regulation of tumorigenesis-related genes in human colon cancer. Oncogene 30:398-409 (2011). WB ; Human . PubMed: 20838379
  • Mathis JM  et al. Genetic Incorporation of Human Metallothionein into the Adenovirus Protein IX for Non-Invasive SPECT Imaging. PLoS One 6:e16792 (2011). WB ; Human . PubMed: 21347423
  • Peterson SM  et al. Global gene expression analysis reveals dynamic and developmental stage-dependent enrichment of lead-induced neurological gene alterations. Environ Health Perspect 119:615-21 (2011). PubMed: 21147602
  • Wang Q  et al. Analysis of metallotionein expression and antioxidant enzyme activities in Meretrix meretrix larvae under sublethal cadmium exposure. Aquat Toxicol 100:321-8 (2010). IHC-Fr . PubMed: 20869127
  • Wang L  et al. Effects of lead and/or cadmium on the expression of metallothionein in the kidney of rats. Biol Trace Elem Res 129:190-9 (2009). IHC-P ; Rat . PubMed: 19096765
  • Gonçalves I  et al. Transthyretin interacts with metallothionein 2. Biochemistry 47:2244-51 (2008). IHC-P ; Rat . PubMed: 18237193
  • Oakley MS  et al. Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. Infect Immun 76:4518-29 (2008). PubMed: 18644885
  • Lee WW  et al. Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling. Rejuvenation Res 11:1001-11 (2008). Flow Cyt ; Human . PubMed: 19072254
  • Girnun GD  et al. Synergy between PPARgamma ligands and platinum-based drugs in cancer. Cancer Cell 11:395-406 (2007). PubMed: 17482130

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