Overview

  • Product name

    Methazolamide, Carbonic anhydrase inhibitor
  • Description

    Potent, cell-permeable carbonic anhydrase inhibitor
  • Biological description

    Potent, cell-permeable carbonic anhydrase inhibitor (Ki values are 50, 14 and 36 nM for hCA I, hCA II and bCA IV isoforms respectively). Shows diuretic and antidiabetic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    554-57-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(3-Methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide
  • Molecular weight

    236.27
  • Molecular formula

    C5H8N4O3S2
  • PubChem identifier

    4100
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)N=C1N(N=C(S1)S(=O)(=O)N)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Pickerodt PA  et al. Pulmonary vasodilation by acetazolamide during hypoxia: impact of methyl-group substitutions and administration route in conscious, spontaneously breathing dogs. J Appl Physiol (1985) 116:715-23 (2014). Read more (PubMed: 24481964) »
  • Konstantopoulos N  et al. Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo. Diabetes 61:2146-54 (2012). Read more (PubMed: 22586591) »
  • Akiba Y  et al. Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Gastroenterology 131:142-52 (2006). Read more (PubMed: 16831598) »

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