Overview

  • Product name

    Methoxsalen, CYP2A6 inhibitor
  • Description

    Potent, selective CYP2A6 inhibitor
  • Alternative names

    • Oxsoralen
  • Biological description

    Potent, selective CYP2A6 inhibitor (Ki =0.8 μM). Completely inhibits nicotine metabolism. Orally active. Cross-linking and photosensitizing agent. Active in vivo and in vitro.
  • CAS Number

    298-81-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    9-Methoxyfuro[3,2-g]chromen-7-one
  • Molecular weight

    216.19
  • Molecular formula

    C12H8O4
  • PubChem identifier

    4114
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Alsharari SD  et al. Pharmacokinetic and pharmacodynamics studies of nicotine after oral administration in mice: effects of methoxsalen, a CYP2A5/6 inhibitor. Nicotine Tob Res 16:18-25 (2014). Read more (PubMed: 23884323) »
  • Damaj MI  et al. Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice. J Pharmacol Exp Ther 320:250-7 (2007). Read more (PubMed: 17021260) »
  • Zhang W  et al. Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. Drug Metab Dispos 29:897-902 (2001). Read more (PubMed: 11353760) »

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