Methoxy-X04, amyloid beta fluorescent marker (ab142818)

Overview

  • Product name

    Methoxy-X04, amyloid beta fluorescent marker
  • Description

    Blood-brain barrier permeable amyloid β fluorescent marker
  • Biological description

    Blood-brain barrier permeable amyloid β fluorescent marker. Blue fluorophore. Derivative of Congo Red (ab145645) and Chrysamine G. Selectively binds fibrillar β-sheet deposits with high affinity (Ki = 26.8 nM). Detects plaques, tangles and cerebrovascular amyloid in vivo.

  • Purity

    > 98%
  • CAS Number

    863918-78-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,5-Bis(2-(4-hydroxyphenyl)vinyl)anisole

  • Molecular weight

    344.41
  • Molecular formula

    C23H20O3
  • PubChem identifier

    16049314
  • Storage instructions

    Store at +4°C.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 20 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COc2cc(cc(/C=C/c1ccc(O)cc1)c2)/C=C/c3ccc(O)cc3
  • Source

    Synthetic

References

This product has been referenced in:

  • Boländer A  et al. Synthesis of methoxy-X04 derivatives and their evaluation in Alzheimer's disease pathology. Neurodegener Dis 13:209-13 (2014). Read more (PubMed: 24080522) »
  • Burgess A  et al. Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy. J Control Release 192:243-8 (2014). Read more (PubMed: 25107692) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142818.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up