Key features and details
- Thiazide diuretic, used to treat high blood pressure and fluid retention
- CAS Number: 135-07-9
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameMethyclothiazide, Thiazide diuretic
DescriptionThiazide diuretic, used to treat high blood pressure and fluid retention
- 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Substituted benzothiadiazide. Exhibits an inhibitory effect on Ca2+ contracture which is significantly but not totally abolished by an NO synthase inhibitor in spontaneously hypertensive rats (SHR) aortic rings with functional endothelium. Induces endothelium-dependent inhibition of the vasoconstrictor responses to norepinephrine and arginine vasopressin only in aortas from SHR rather than normotensive Wistar Kyoto rats (WKY). Inhibits renin release in rat kidney slices.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145735 has not yet been referenced specifically in any publications.