Methyl Arachidonyl Fluorophosphonate, irreversible cPLA2 and iPLA2 inhibitor (ab141763)

Overview

  • Product name

    Methyl Arachidonyl Fluorophosphonate, irreversible cPLA2 and iPLA2 inhibitor
  • Description

    Selective, active site directed, irreversible cPLA2 and iPLA2 inhibitor. Potent FAAH inhibitor.
  • Biological description

    Selective, active site directed, irreversible cPLA2 and iPLA2 inhibitor. Potent FAAH inhibitor (IC50 = 2.5 nM). Inhibits A23187 (ab120287, ab142245, ab142244)-induced arachidonic acid release from platelets (IC50 = 600 nM). Potent, irreversible anandamide amidase inhibitor. Prolongs and intensifies aerobic exercise-induced antinociceptive effects in vivo.
  • Purity

    > 98%
  • CAS Number

    188404-10-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ong WY  et al. Synthetic and natural inhibitors of phospholipases A2: their importance for understanding and treatment of neurological disorders. ACS Chem Neurosci 6:814-31 (2015). Read more (PubMed: 25891385) »
  • Lucas KK & Dennis EA Distinguishing phospholipase A2 types in biological samples by employing group-specific assays in the presence of inhibitors. Prostaglandins Other Lipid Mediat 77:235-48 (2005). Read more (PubMed: 16099408) »
  • McHowat J & Creer MH Calcium-independent phospholipase A2 in isolated rabbit ventricular myocytes. Lipids 33:1203-12 (1998). Read more (PubMed: 9930406) »
  • Deutsch DG  et al. Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol 53:255-60 (1997). Read more (PubMed: 9065728) »
  • Lio YC  et al. Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta 1302:55-60 (1996). Read more (PubMed: 8695655) »

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