Methyldopa sesquihydrate, alpha2 adrenoceptor agonist (ab142911)

Overview

  • Product name

    Methyldopa sesquihydrate, alpha2 adrenoceptor agonist
  • Description

    α2 adrenoceptor agonist. Competitive DOPA decarboxylase inhibitor.
  • Biological description

    α2 adrenoceptor agonist. Competitive DOPA decarboxylase inhibitor. Centrally and peripherally acting. Depletes tissue levels of norepinephrine. Shows antihypertensive effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    41372-08-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • van Giersbergen PL  et al. Possible involvement of beta endorphin(1-31) and dynorphin(1-13) in the central hypotensive mechanism of action of alpha methyldopa. Neuroendocrinology 49:71-9 (1989). Read more (PubMed: 2566129) »
  • NTP Toxicology and Carcinogenesis Studies of alpha-Methyldopa Sesquihydrate (CAS No. 41372-08-1) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser 348:1-184 (1989). Read more (PubMed: 12704436) »
  • Zavisca FG  et al. Mechanism of action of methyldopa in the rat. Role of 3-O-methylated metabolites. Circ Res 45:684-90 (1979). Read more (PubMed: 487531) »

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