Overview

  • Product name

    Methysticin, NaV channel inhibitor
  • Description

    CYP1A1 inducer. NaV channel inhibitor.
  • Biological description

    CYP1A1 inducer. NaV channel inhibitor. Reversibly blocks epileptiform activity (IC50 = 10-100 μM). Shows anxiolytic, anti-ischemic, anticonvulsant and neuroprotective effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    495-85-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R)-2-[(E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one
  • Molecular weight

    274.27
  • Molecular formula

    C15H14O5
  • PubChem identifier

    5281567
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=O)OC(C1)C=CC2=CC3=C(C=C2)OCO3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Magura EI  et al. Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons. Neuroscience 81:345-51 (1997). Read more (PubMed: 9300426) »
  • Schmitz D  et al. Effects of methysticin on three different models of seizure like events studied in rat hippocampal and entorhinal cortex slices. Naunyn Schmiedebergs Arch Pharmacol 351:348-55 (1995). Read more (PubMed: 7630425) »
  • Backhauss C & Krieglstein J Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur J Pharmacol 215:265-9 (1992). Read more (PubMed: 1396990) »

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