Overview

  • Product name

    MG-115, proteasome inhibitor
  • Description

    Potent, reversible proteasome inhibitor
  • Alternative names

    • Z-Leu-Leu-Nva-CHO
  • Biological description

    Potent, reversible 20S and 26S proteasome inhibitor (Ki values are 21 and 35 nM, respectively). Inhibits chymotrypsin-like activity. Shows proapoptotic effect in vitro.
  • Purity

    > 95%
  • CAS Number

    133407-86-0
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    461.59
  • Molecular formula

    C25H39N3O5
  • Sequence

    LLX (Modifications: N-terminal benzyloxycarbonyl; C-terminal aldehyde; X-3 = Nva)
  • PubChem identifier

    9868928
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
  • Source

    Synthetic

References

This product has been referenced in:

  • Boutillier AL  et al. Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway. Eur J Neurosci 11:441-8 (1999). Read more (PubMed: 10051745) »
  • Glockzin S  et al. Activation of the cell death program by nitric oxide involves inhibition of the proteasome. J Biol Chem 274:19581-6 (1999). Read more (PubMed: 10391892) »
  • Rock KL  et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761-71 (1994). Read more (PubMed: 8087844) »

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