MG-132 (Ethanol Solution), proteasome inhibitor (ab147047)

Overview

  • Product name

    MG-132 (Ethanol Solution), proteasome inhibitor
  • Description

    Cell-permeable, potent, reversible proteasome inhibitor
  • Alternative names

    • Z-Leu-Leu-Leu-CHO
    • Z-LLL-CHO
  • Biological description

    Cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation. Anticancer properties in vitro and in vivo.

  • Purity

    > 98%
  • General notes

    Desiccate at -20°C in a spark free freezer [product contains a flammable solvent (UN1170: ethanol solution, PG II)]. Protect from air and moisture.

  • CAS Number

    133407-82-6
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    475.62
  • Molecular formula

    C26H41N3O5
  • Sequence

    LLL (Modifications : N-terminal benzyloxycarbonyl; C-terminal aldehyde)
  • PubChem identifier

    462382
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Supplied in ethanol (10 mM)
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

Associated products

References

This product has been referenced in:

  • Zanotto-Filho A  et al. Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling. Invest New Drugs 30:2252-62 (2012). Read more (PubMed: 22367315) »
  • Caron AZ  et al. The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice. BMC Musculoskelet Disord 12:185 (2011). Read more (PubMed: 21843349) »
  • MacLaren AP  et al. p53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells. Cell Death Differ 8:210-8 (2001). Read more (PubMed: 11319603) »
  • Banerjee D & Liefshitz A Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res 21:3941-7 (0). Read more (PubMed: 11911275) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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