Key features and details
- Cell-permeable, potent, reversible proteasome inhibitor
- CAS Number: 133407-82-6
- Purity: > 98%
- Supplied in ethanol (10 mM)
- Form / State: Liquid
- Source: Synthetic
Product nameMG-132 (Ethanol Solution), proteasome inhibitor
DescriptionCell-permeable, potent, reversible proteasome inhibitor
Cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation. Anticancer properties in vitro and in vivo.
Desiccate at -20°C in a spark free freezer [product contains a flammable solvent (UN1170: ethanol solution, PG II)]. Protect from air and moisture.
SequenceLLL (Modifications : N-terminal benzyloxycarbonyl; C-terminal aldehyde)
Storage instructionsShipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
Solubility overviewSupplied in ethanol (10 mM)
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab147047 has been referenced in 1 publication.
- Chen W et al. MARCH8 Suppresses Tumor Metastasis and Mediates Degradation of STAT3 and CD44 in Breast Cancer Cells. Cancers (Basel) 13:N/A (2021). PubMed: 34067416