Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Our Abpromise guarantee covers the use of ab168485 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at an assay dependent concentration. The recommended starting value of ab168485 is 30-40 µl, plus 10 µl Protein a magnetic beads, for a total reaction volume of 500 µl.|
FunctionGlycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis.
Tissue specificityWidely expressed. Strongly overexpressed in pancreatic cancer.
PathwayProtein modification; protein glycosylation.
Sequence similaritiesBelongs to the glycosyltransferase 54 family.
Cellular localizationGolgi apparatus membrane.
- Information by UniProt
- 3-D-mannoside beta-1 antibody
- 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B antibody
- 4-N-acetylglucosaminyltransferase IVb antibody
ab168485 has not yet been referenced specifically in any publications.