Overview

  • Product name

  • Description

    Rabbit polyclonal to MGEA5/OGA
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Chicken, Cow, Human
  • Immunogen

    Recombinant fragment within Human MGEA5/OGA (internal sequence). The exact sequence is proprietary.
    Database link: O60502

  • Positive control

    • IHC-P: Mouse pancreas tissue; Rat hind brain tissue.
  • General notes

    Previously labelled as MGEA5

Properties

Applications

Our Abpromise guarantee covers the use of ab228723 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.

Target

  • Function

    Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
    Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
  • Tissue specificity

    Ubiquitous. Shows highest expression in the brain, placenta and pancreas.
  • Sequence similarities

    Belongs to the glycosyl hydrolase 84 family.
  • Post-translational
    modifications

    Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
  • Cellular localization

    Cytoplasm and Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Beta-hexosaminidase antibody
    • Beta-N-acetylglucosaminidase antibody
    • Beta-N-acetylhexosaminidase antibody
    • Bifunctional protein NCOAT antibody
    • HEXC antibody
    • Hyaluronidase in meningioma antibody
    • KIAA0679 antibody
    • MEA5 antibody
    • Meningioma expressed antigen 5 antibody
    • Meningioma-expressed antigen 5 antibody
    • MGEA 5 antibody
    • Mgea5 antibody
    • N-acetyl-beta-D-glucosaminidase antibody
    • N-acetyl-beta-glucosaminidase antibody
    • NCOAT antibody
    • Nuclear cytoplasmic O GlcNAcase and acetyltransferase antibody
    • Nuclear cytoplasmic O-GlcNAcase and acetyltransferase antibody
    • OGA antibody
    • OGA_HUMAN antibody
    • Protein O-GlcNAcase antibody
    see all

Images

  • Paraffin-embedded mouse pancreas tissue stained for MGEA5/OGA using ab228723 at 1/500 dilution in immunohistochemical analysis.

  • Paraffin-embedded rat hind brain tissue stained for MGEA5/OGA using ab228723 at 1/500 dilution in immunohistochemical analysis.

References

ab228723 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab228723.
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