Key features and details
- Mouse monoclonal [MGO-1] to MGO-modified proteins
- Suitable for: WB, IHC-P, ELISA
- Reacts with: Human, a wide range of other species
- Isotype: IgG1
Product nameAnti-MGO-modified proteins antibody [MGO-1]
DescriptionMouse monoclonal [MGO-1] to MGO-modified proteins
Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
Species reactivityReacts with: Human, a wide range of other species
MGO-modified proteins conjugated to KLH.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: 0.1% BSA, 99% PBS
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab125158 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration.|
|ELISA||Use at an assay dependent concentration.|
RelevanceMethylglyoxal (MGO) is an endogenous product of glucose metabolism. Increased production and accumulation of methylglyoxal (MGO), as well as increased modification of proteins by glycoxidation, are hallmarks of aging and diabetes. MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells. A number of studies have shown that MGO levels are significantly elevated in patients with Type 2 Diabetes and correlates well with fasting plasma glucose and hemoglobin A1c (HbA1c) levels. Moreover, increased formation of the MGO is implicated in renal dysfunction and is known to be involved in the development of DN (diabetic nephropathy).
ab125158 has not yet been referenced specifically in any publications.