Overview

  • Product name

  • Description

    Rabbit polyclonal to MGP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Orangutan
  • Immunogen

    Recombinant fragment corresponding to Human MGP aa 24-97.
    Sequence:

    ESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREAC DDYRLCERYAMVYGYNAAYNRYFR


    Database link: P08493

  • Positive control

    • IHC-P: Human nasopharynx tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab224367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
  • Involvement in disease

    Defects in MGP are the cause of Keutel syndrome (KS) [MIM:245150]. KS is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
  • Sequence similarities

    Belongs to the osteocalcin/matrix Gla protein family.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Post-translational
    modifications

    Requires vitamin K-dependent gamma-carboxylation for its function.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cell growth inhibiting gene 36 protein antibody
    • Cell growth-inhibiting gene 36 protein antibody
    • GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX antibody
    • GIG36 antibody
    • Matrix Gla protein antibody
    • MGLAP antibody
    • MGP antibody
    • MGP_HUMAN antibody
    • NTI antibody
    see all

Images

  • Paraffin-embedded human nasopharynx tissue stained for MGP using ab224367 at 1/200 dilution in immunohistochemical analysis.

References

ab224367 has not yet been referenced specifically in any publications.

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