Anti-MGRN1 antibody (ab101997)

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Overview

  • Product name

    Anti-MGRN1 antibody
    See all MGRN1 primary antibodies

  • Description

    Rabbit polyclonal to MGRN1

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IPmore details
    Unsuitable for: WB

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla

  • Immunogen

    Synthetic peptide corresponding to Human MGRN1 aa 505-555.
    Database link: NP_001135761.1

  • Positive control

    • HeLa whole cell lysate.

  • General notes

    Previously labelled as RNF156. 

Properties

Applications

Our Abpromise guarantee covers the use of ab101997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.

    • Target

    • Function

      E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.

    • Pathway

      Protein modification; protein ubiquitination.

    • Sequence similarities

      Contains 1 RING-type zinc finger.

    • Domain

      The RING finger is required for ubiquitin ligase activity.

    • Post-translational
      modifications

      Autoubiquitinated in vitro.

    • Cellular localization

      Cytoplasm > cytosol. Cell membrane; Early endosome. The endosomal localization is dependent on the interaction with TSG101 and Cytoplasm > cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
    • Information by UniProt

    • Database links

      • Alternative names

        • E3 ubiquitin-protein ligase MGRN1 antibody
        • KIAA0544 antibody
        • Mahogunin ring finger 1 antibody
        • Mahogunin RING finger protein 1 antibody
        • MGRN 1 antibody
        • Mgrn1 antibody
        • MGRN1_HUMAN antibody
        • Probable E3 ubiquitin protein ligase MGRN1 antibody
        • RING finger protein 156 antibody
        • RNF 156 antibody
        • RNF156 antibody
        see all

      References

      ab101997 has not yet been referenced specifically in any publications.

      Publishing research using ab101997? Please let us know so that we can cite the reference in this datasheet.

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