Overview

  • Product name
    Anti-mH2A2 antibody
    See all mH2A2 primary antibodies
  • Description
    Rabbit polyclonal to mH2A2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment corresponding to Human mH2A2 aa 1-197.
    Database link: Q9P0M6

  • Positive control
    • A431 and mouse brain whole cell lysate.
  • General notes
    Keep as concentrated solution.

    Previously labelled as Macro H2A.2.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab154687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.

Target

  • Function
    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
  • Sequence similarities
    Contains 1 histone H2A domain.
    Contains 1 Macro domain.
  • Cellular localization
    Nucleus. Chromosome. Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.
  • Information by UniProt
  • Database links
    • Alternative names
      • Core histone macro H2A2.2 antibody
      • Core histone macro-H2A.2 antibody
      • Core histone macroH2A2.2 antibody
      • H2A histone family member Y2 antibody
      • H2AFY2 antibody
      • H2AW_HUMAN antibody
      • Histone macroH2A2 antibody
      • Macro H2A.2 antibody
      • Macro H2A2 antibody
      • MacroH2A.2 antibody
      • MacroH2A2 antibody
      • mH2A2 antibody
      see all

    Images

    • Western blot - Anti-mH2A2 antibody (ab154687)
      Western blot - Anti-mH2A2 antibody (ab154687)
      Anti-mH2A2 antibody (ab154687) at 1/1000 dilution + A431 whole cell lysate at 30 µg

      Predicted band size: 40 kDa



      10% SDS PAGE
    • Western blot - Anti-mH2A2 antibody (ab154687)
      Western blot - Anti-mH2A2 antibody (ab154687)
      Anti-mH2A2 antibody (ab154687) at 1/500 dilution + Mouse brain whole cell lysate at 50 µg

      Predicted band size: 40 kDa



      10% SDS PAGE

    References

    ab154687 has not yet been referenced specifically in any publications.

    Publishing research using ab154687? Please let us know so that we can cite the reference in this datasheet.

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