Key features and details
- Rabbit polyclonal to Mib1/Mindbomb
- Suitable for: IHC - Wholemount
- Reacts with: Zebrafish
- Isotype: IgG
Product nameAnti-Mib1/Mindbomb antibody
See all Mib1/Mindbomb primary antibodies
DescriptionRabbit polyclonal to Mib1/Mindbomb
Tested applicationsSuitable for: IHC - Wholemountmore details
Species reactivityReacts with: Zebrafish
Recombinant fragment within Zebrafish Mib1/Mindbomb aa 2-303. The exact sequence is proprietary.
Database link: Q804S5
- 2 days-post-fertilization zebrafish embryo.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab210547 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC - Wholemount||1/50 - 1/500.|
FunctionE3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Tissue specificityWidely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesContains 9 ANK repeats.
Contains 2 MIB/HERC2 domains.
Contains 3 RING-type zinc fingers.
Contains 1 ZZ-type zinc finger.
modificationsUbiquitinated. Possibly via autoubiquitination.
Cellular localizationCytoplasm. Cell membrane. Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear.
- Information by UniProt
- DAPK-interacting protein 1 antibody
- Dip 1 antibody
- DIP-1 antibody
ab210547 has not yet been referenced specifically in any publications.